Depressed natural and lectin-dependent cell-mediated cytotoxicity against adherent hep-2 cells in patients with systemic lupus erythematosus

A. Perl, R. Gonzalez-Cabello, I. Láng, P. Gergely

Research output: Article

6 Citations (Scopus)

Abstract

Natural cell-mediated cytotoxicity /NCMC/ was evaluated using human adherent 3H-thymidine-prelabelled HEp-2 epipharynx carcinoma cells as targets at 50:1 effector-target cell ratio in a 24 hr assay. For lectin-dependent cell-mediated cytotoxicity /LDCC/ studies cultures contained also 25/Ug/ml concanavalin A /Con A/. Peripheral blood mononuclear cells /PBMC/ of nine patients with active systemic lupus erythematosus /SLE/ failed to exert NCMC or LDCC against HEp-2 targets. In contrast, an increased adherence /decreased detachment from the monolayer/ of HEp-2 target cells was observed in the presence of PBM3 from SLE patients that was further promoted by the addition of Con A during LDCC assay.

Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalImmunological Investigations
Volume11
Issue number6
DOIs
Publication statusPublished - jan. 1 1982

ASJC Scopus subject areas

  • Immunology

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