Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons

Szabolcs Káli, T. Freund

Research output: Conference contribution

Abstract

Area CA1 of the hippocampus contains a population of pyramidal cells, accompanied by a diverse array of inhibitory interneurons, which are believed to modulate the activity and plasticity of pyramidal neurons. We created appropriately detailed models of hippocampal principal cells and interneurons, which were then used to explore how these different cell types interact within the hippocampal network. In particular, we show that different input pathways drive pyramidal cells with a different efficacy, and that the relative efficacy of different inputs can be modulated by various neurotransmitters and, in a more specific manner, by dendritic inhibition. Feedback inhibition could also selectively gate backpropagating action potentials.

Original languageEnglish
Title of host publicationIEEE International Conference on Neural Networks - Conference Proceedings
Pages615-620
Number of pages6
Volume1
Publication statusPublished - 2004
Event2004 IEEE International Joint Conference on Neural Networks - Proceedings - Budapest, Hungary
Duration: júl. 25 2004júl. 29 2004

Other

Other2004 IEEE International Joint Conference on Neural Networks - Proceedings
CountryHungary
CityBudapest
Period7/25/047/29/04

Fingerprint

Neurons
Plasticity
Cells
Modulation
Feedback
Processing

ASJC Scopus subject areas

  • Software

Cite this

Káli, S., & Freund, T. (2004). Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons. In IEEE International Conference on Neural Networks - Conference Proceedings (Vol. 1, pp. 615-620)

Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons. / Káli, Szabolcs; Freund, T.

IEEE International Conference on Neural Networks - Conference Proceedings. Vol. 1 2004. p. 615-620.

Research output: Conference contribution

Káli, S & Freund, T 2004, Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons. in IEEE International Conference on Neural Networks - Conference Proceedings. vol. 1, pp. 615-620, 2004 IEEE International Joint Conference on Neural Networks - Proceedings, Budapest, Hungary, 7/25/04.
Káli S, Freund T. Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons. In IEEE International Conference on Neural Networks - Conference Proceedings. Vol. 1. 2004. p. 615-620
Káli, Szabolcs ; Freund, T. / Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons. IEEE International Conference on Neural Networks - Conference Proceedings. Vol. 1 2004. pp. 615-620
@inproceedings{b7e6b584398749c6b5383ba638c07202,
title = "Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons",
abstract = "Area CA1 of the hippocampus contains a population of pyramidal cells, accompanied by a diverse array of inhibitory interneurons, which are believed to modulate the activity and plasticity of pyramidal neurons. We created appropriately detailed models of hippocampal principal cells and interneurons, which were then used to explore how these different cell types interact within the hippocampal network. In particular, we show that different input pathways drive pyramidal cells with a different efficacy, and that the relative efficacy of different inputs can be modulated by various neurotransmitters and, in a more specific manner, by dendritic inhibition. Feedback inhibition could also selectively gate backpropagating action potentials.",
author = "Szabolcs K{\'a}li and T. Freund",
year = "2004",
language = "English",
volume = "1",
pages = "615--620",
booktitle = "IEEE International Conference on Neural Networks - Conference Proceedings",

}

TY - GEN

T1 - Dendritic processing in hippocampal pyramidal cells and its modulation by inhibitory interneurons

AU - Káli, Szabolcs

AU - Freund, T.

PY - 2004

Y1 - 2004

N2 - Area CA1 of the hippocampus contains a population of pyramidal cells, accompanied by a diverse array of inhibitory interneurons, which are believed to modulate the activity and plasticity of pyramidal neurons. We created appropriately detailed models of hippocampal principal cells and interneurons, which were then used to explore how these different cell types interact within the hippocampal network. In particular, we show that different input pathways drive pyramidal cells with a different efficacy, and that the relative efficacy of different inputs can be modulated by various neurotransmitters and, in a more specific manner, by dendritic inhibition. Feedback inhibition could also selectively gate backpropagating action potentials.

AB - Area CA1 of the hippocampus contains a population of pyramidal cells, accompanied by a diverse array of inhibitory interneurons, which are believed to modulate the activity and plasticity of pyramidal neurons. We created appropriately detailed models of hippocampal principal cells and interneurons, which were then used to explore how these different cell types interact within the hippocampal network. In particular, we show that different input pathways drive pyramidal cells with a different efficacy, and that the relative efficacy of different inputs can be modulated by various neurotransmitters and, in a more specific manner, by dendritic inhibition. Feedback inhibition could also selectively gate backpropagating action potentials.

UR - http://www.scopus.com/inward/record.url?scp=10944256656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10944256656&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:10944256656

VL - 1

SP - 615

EP - 620

BT - IEEE International Conference on Neural Networks - Conference Proceedings

ER -