Defects in innate immunity: Receptors and signaling components

Melinda Erdős, László Maródi, Seyed Alireza Mahdaviani, Sergio D. Rosenzweig, Joachim Roesler, Nima Rezaei

Research output: Chapter


The innate immune system is the first-line host defense against microbial pathogens and is mediated by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLR). PRPs consist of secreted and circulating proteins, and intracellular and transmembrane signal-transducing components [1]. They recognize pathogen-associated molecular patterns (PAMPs).

Original languageEnglish
Title of host publicationClinical Cases in Primary Immunodeficiency Diseases
Subtitle of host publicationA Problem-Solving Approach
PublisherSpringer Berlin Heidelberg
Number of pages29
ISBN (Electronic)9783642317859
ISBN (Print)9783642317842
Publication statusPublished - jan. 1 2012

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Erdős, M., Maródi, L., Mahdaviani, S. A., Rosenzweig, S. D., Roesler, J., & Rezaei, N. (2012). Defects in innate immunity: Receptors and signaling components. In Clinical Cases in Primary Immunodeficiency Diseases: A Problem-Solving Approach (pp. 279-307). Springer Berlin Heidelberg.