Decreased Number of Mitochondria in Leukoaraiosis

Z. Szolnoki, M. Szekeres, Istvan Szaniszlo, Gyorgy Balda, Anita Bodor, A. Kondacs, Y. Mándi, F. Somogyvári

Research output: Article

2 Citations (Scopus)

Abstract

Background and Aims: Leukoaraiosis (LA), one of the most frequent causes of an age-associated cognitive decline, can be associated with a poor quality of life, leading overall to far-reaching public health problems. Chronic hypoxia of the white matter of the brain may be a factor triggering this entity. LA may develop as a consequence of chronically insufficient cellular energy production and the accumulation of free radicals. Methods: In this context, after hypothesizing that the number of healthy mitochondria can be crucial in this complex process, a case-control LA study was carried out in which we analyzed the numbers of deleted and non-deleted mitochondria (the common D-loop deletion) per white blood cell. A total of 234 patients with LA and 123 MRI alteration-free subjects served as a control group. Results: Interestingly, it emerged that the ratio of deleted relative to non-deleted mitochondria is strongly associated with the risk of LA. The calculated K ratio in the LA group was significantly lower than the K ratio in the controls (LA: K 0.37 95% CI 0.05; controls: K 0.48, 95% CI 0.076, p <0.001). Conclusions: Our study suggests that the ratio of the dmDNA and mDNA can be of great importance in the pathogenesis of LA.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalArchives of Medical Research
Volume46
Issue number8
DOIs
Publication statusPublished - nov. 1 2015

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Leukoaraiosis
Mitochondria
Free Radicals
Case-Control Studies
Leukocytes
Public Health
Quality of Life
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Decreased Number of Mitochondria in Leukoaraiosis. / Szolnoki, Z.; Szekeres, M.; Szaniszlo, Istvan; Balda, Gyorgy; Bodor, Anita; Kondacs, A.; Mándi, Y.; Somogyvári, F.

In: Archives of Medical Research, Vol. 46, No. 8, 01.11.2015, p. 604-608.

Research output: Article

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AU - Szolnoki, Z.

AU - Szekeres, M.

AU - Szaniszlo, Istvan

AU - Balda, Gyorgy

AU - Bodor, Anita

AU - Kondacs, A.

AU - Mándi, Y.

AU - Somogyvári, F.

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