Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies

Johanna Dömötör, B. Clemens, Szilvia Puskás, I. Fekete

Research output: Article

1 Citation (Scopus)

Abstract

Objective To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients. Patients and methods EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5–8.0 Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome. Results Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p < 0.001). Significance An EEG-based biomarker that predicts successful drug treatment was described.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalEpilepsy Research
Volume133
DOIs
Publication statusPublished - júl. 1 2017

Fingerprint

Juvenile Myoclonic Epilepsy
Electroencephalography
Seizures
Therapeutics
Absence Epilepsy
Electromagnetic Phenomena
Artifacts
Biomarkers
Tomography
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

@article{14f304a52bea4133bef1ca812004ca7c,
title = "Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies",
abstract = "Objective To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients. Patients and methods EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5–8.0 Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome. Results Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p < 0.001). Significance An EEG-based biomarker that predicts successful drug treatment was described.",
keywords = "Absence epilepsy, Current source density, EEG background activity, Myoclonic epilepsy, Treatment efficiency",
author = "Johanna D{\"o}m{\"o}t{\"o}r and B. Clemens and Szilvia Pusk{\'a}s and I. Fekete",
year = "2017",
month = "7",
day = "1",
doi = "10.1016/j.eplepsyres.2017.03.006",
language = "English",
volume = "133",
pages = "1--5",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",

}

TY - JOUR

T1 - Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies

AU - Dömötör, Johanna

AU - Clemens, B.

AU - Puskás, Szilvia

AU - Fekete, I.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Objective To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients. Patients and methods EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5–8.0 Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome. Results Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p < 0.001). Significance An EEG-based biomarker that predicts successful drug treatment was described.

AB - Objective To investigate relationship between treatment efficiency and EEG background activity changes in absence epilepsy (AE) and juvenile myoclonic epilepsy (JME) patients. Patients and methods EEGs of 31 patients were analysed before treatment and after six months of treatment. Three minutes of artifact-free waking EEG background activity (without epileptiform potentials) were analysed for each patient in both conditions. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography). Average of all the voxel-wise current source density (CSD) values within the 0.5–8.0 Hz frequency range was computed for each EEG. Fischer's exact test was used to investigate association between the global CSD changes and the therapeutic outcome. Results Tight connection was demonstrated between seizure freedom and decreased CSD, and between persisting seizures and increased CSD (p < 0.001). Significance An EEG-based biomarker that predicts successful drug treatment was described.

KW - Absence epilepsy

KW - Current source density

KW - EEG background activity

KW - Myoclonic epilepsy

KW - Treatment efficiency

UR - http://www.scopus.com/inward/record.url?scp=85017130578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017130578&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2017.03.006

DO - 10.1016/j.eplepsyres.2017.03.006

M3 - Article

C2 - 28391029

AN - SCOPUS:85017130578

VL - 133

SP - 1

EP - 5

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

ER -