The function of short lived and concanavalin-A activated suppressor T cells of peripheral blood was studied in patients with thyrotoxicosis and normal individuals. It was found that the activity of short lived and concanavalin-A activated suppressor T cells decreased in untreated patients. The function of concanavalin-A activated suppressor cells relatively increased in the euthyroid stage induced by methimazole treatment but failed to reach the normal level. Both the short lived and Concanavalin-A activated suppressor cell activity proved to be in inverse relationship with titres of anti-thyroglobulin antibodies and transformation indices to human thyroglobulin. These findings suggest a possible role of suppressor T cell function in the pathogenesis of Graves' disease.
|Number of pages||5|
|Publication status||Published - dec. 1 1979|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)