Decrease of concanavalin-A activated and short lived suppressor t cell function in thyrotoxicosis

Cs Balazs, A. Leovey, L. Bordan

Research output: Article

32 Citations (Scopus)

Abstract

The function of short lived and concanavalin-A activated suppressor T cells of peripheral blood was studied in patients with thyrotoxicosis and normal individuals. It was found that the activity of short lived and concanavalin-A activated suppressor T cells decreased in untreated patients. The function of concanavalin-A activated suppressor cells relatively increased in the euthyroid stage induced by methimazole treatment but failed to reach the normal level. Both the short lived and Concanavalin-A activated suppressor cell activity proved to be in inverse relationship with titres of anti-thyroglobulin antibodies and transformation indices to human thyroglobulin. These findings suggest a possible role of suppressor T cell function in the pathogenesis of Graves' disease.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalBiomedicine
Volume30
Issue number3
Publication statusPublished - dec. 1 1979

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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