Cytotoxic compounds from endemic Arnebia purpurea

Merve Yuzbasioglu, Ayse Kuruuzum-Uz, Zuhal Guvenalp, A. Simon, Gabór Tóth, U. Sebnem Harput, Cavit Kazaz, Bilgehan Bilgili, Hayri Duman, Iclal Saracoglu, L. Omur Demirezer

Research output: Article

4 Citations (Scopus)

Abstract

Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

Original languageEnglish
Pages (from-to)595-596
Number of pages2
JournalNatural Product Communications
Volume10
Issue number4
Publication statusPublished - ápr. 1 2015

Fingerprint

Arnebia
Boraginaceae
kaempferol
Oleanolic Acid
rutin
naphthoquinones
isorhamnetin
oleanolic acid
Naphthoquinones
Triterpenes
Fibrosarcoma
Phytochemicals
Glycosides
Flavonoids
Doxorubicin
rosmarinic acid
fibrosarcoma
doxorubicin
sitosterols
phenolic acids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yuzbasioglu, M., Kuruuzum-Uz, A., Guvenalp, Z., Simon, A., Tóth, G., Harput, U. S., ... Demirezer, L. O. (2015). Cytotoxic compounds from endemic Arnebia purpurea. Natural Product Communications, 10(4), 595-596.

Cytotoxic compounds from endemic Arnebia purpurea. / Yuzbasioglu, Merve; Kuruuzum-Uz, Ayse; Guvenalp, Zuhal; Simon, A.; Tóth, Gabór; Harput, U. Sebnem; Kazaz, Cavit; Bilgili, Bilgehan; Duman, Hayri; Saracoglu, Iclal; Demirezer, L. Omur.

In: Natural Product Communications, Vol. 10, No. 4, 01.04.2015, p. 595-596.

Research output: Article

Yuzbasioglu, M, Kuruuzum-Uz, A, Guvenalp, Z, Simon, A, Tóth, G, Harput, US, Kazaz, C, Bilgili, B, Duman, H, Saracoglu, I & Demirezer, LO 2015, 'Cytotoxic compounds from endemic Arnebia purpurea', Natural Product Communications, vol. 10, no. 4, pp. 595-596.
Yuzbasioglu M, Kuruuzum-Uz A, Guvenalp Z, Simon A, Tóth G, Harput US et al. Cytotoxic compounds from endemic Arnebia purpurea. Natural Product Communications. 2015 ápr. 1;10(4):595-596.
Yuzbasioglu, Merve ; Kuruuzum-Uz, Ayse ; Guvenalp, Zuhal ; Simon, A. ; Tóth, Gabór ; Harput, U. Sebnem ; Kazaz, Cavit ; Bilgili, Bilgehan ; Duman, Hayri ; Saracoglu, Iclal ; Demirezer, L. Omur. / Cytotoxic compounds from endemic Arnebia purpurea. In: Natural Product Communications. 2015 ; Vol. 10, No. 4. pp. 595-596.
@article{a99857d42cce4887a63ba39403543c93,
title = "Cytotoxic compounds from endemic Arnebia purpurea",
abstract = "Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5{"}-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5{"}-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.",
author = "Merve Yuzbasioglu and Ayse Kuruuzum-Uz and Zuhal Guvenalp and A. Simon and Gab{\'o}r T{\'o}th and Harput, {U. Sebnem} and Cavit Kazaz and Bilgehan Bilgili and Hayri Duman and Iclal Saracoglu and Demirezer, {L. Omur}",
year = "2015",
month = "4",
day = "1",
language = "English",
volume = "10",
pages = "595--596",
journal = "Natural Product Communications",
issn = "1934-578X",
publisher = "Natural Product Communications",
number = "4",

}

TY - JOUR

T1 - Cytotoxic compounds from endemic Arnebia purpurea

AU - Yuzbasioglu, Merve

AU - Kuruuzum-Uz, Ayse

AU - Guvenalp, Zuhal

AU - Simon, A.

AU - Tóth, Gabór

AU - Harput, U. Sebnem

AU - Kazaz, Cavit

AU - Bilgili, Bilgehan

AU - Duman, Hayri

AU - Saracoglu, Iclal

AU - Demirezer, L. Omur

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

AB - Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-mrutinoside, and kaempferol 3-O-(5"-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

UR - http://www.scopus.com/inward/record.url?scp=84933523300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84933523300&partnerID=8YFLogxK

M3 - Article

C2 - 25973485

AN - SCOPUS:84933523300

VL - 10

SP - 595

EP - 596

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

IS - 4

ER -