Cytogenetic profile of primary pituitary germinoma

É Gömöri, D. J. Halbauer, T. Dóczi, E. Balázs, P. Kajtár, L. Pajor

Research output: Article

2 Citations (Scopus)


We present a case of a germinoma in the sellar region of a 10-year-old female patient who presented with a history of polydipsia, polyuria and visual disturbances. The tumor was resected and histologically analyzed. Interphase cytogenetics was performed using chromosome specific (peri)-centromeric DNA probes for all the somatic and X chromosomes on fresh frozen tissues. Fluorescent in situ cell hybridization demonstrated accumulated cytogenetic abnormalities involving significant alterations of chromosome 1, 4, 5/19 and 15. The child was treated postoperatively by radiation and now appears well with only minor neurological deficits. At 3-year follow-up no recurrent tumor mass could be demonstrated.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalJournal of Neuro-Oncology
Issue number3
Publication statusPublished - dec. 1 2000

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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