Cytochemical study of peritoneal macrophages in carrageenan-treated immunosuppressed mice

K. Lapis, J. Tímár, M. Bencsath, T. Van Hanh, L. Kópper

Research output: Article

3 Citations (Scopus)

Abstract

In our examinations the cytochemical characters of the peritoneal macrophages of immunosuppressed mice (Is-PM) were studied. It was stated that the acid phosphatase activity of their lysosomal system decreased in comparison to control cells (N-PM). In Is-PM cells the polyanion content of the cell-coat and the expression of their Con-A receptors decreased, while the glycos- and galactosaminoglycan (GAG) content showed a decrease on the surface of every cell of the population. On the first day following carrageenan treatment, acid phosphatase activity of the cells was very low, the GAG content and the conA receptors of the cell-coat disappeared. The characteristic lysosomal alterations could still be observed on the 6th day after treatment. On the basis of our observations, treatment with carrageenan impaired not only the lysosomal system of macrophages, but the cell surface too. These cytochemical changes may explain the dramatic decrease in macrophage function observed in carrageenan treatment.

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalArchiv fur Geschwulstforschung
Volume50
Issue number5
Publication statusPublished - 1980

Fingerprint

Carrageenan
Peritoneal Macrophages
Glycocalyx
Acid Phosphatase
Macrophages
Population
galactosaminoglycan

ASJC Scopus subject areas

  • Cancer Research

Cite this

@article{3cded1ce52b546c8822c13b317c75541,
title = "Cytochemical study of peritoneal macrophages in carrageenan-treated immunosuppressed mice",
abstract = "In our examinations the cytochemical characters of the peritoneal macrophages of immunosuppressed mice (Is-PM) were studied. It was stated that the acid phosphatase activity of their lysosomal system decreased in comparison to control cells (N-PM). In Is-PM cells the polyanion content of the cell-coat and the expression of their Con-A receptors decreased, while the glycos- and galactosaminoglycan (GAG) content showed a decrease on the surface of every cell of the population. On the first day following carrageenan treatment, acid phosphatase activity of the cells was very low, the GAG content and the conA receptors of the cell-coat disappeared. The characteristic lysosomal alterations could still be observed on the 6th day after treatment. On the basis of our observations, treatment with carrageenan impaired not only the lysosomal system of macrophages, but the cell surface too. These cytochemical changes may explain the dramatic decrease in macrophage function observed in carrageenan treatment.",
author = "K. Lapis and J. T{\'i}m{\'a}r and M. Bencsath and {Van Hanh}, T. and L. K{\'o}pper",
year = "1980",
language = "English",
volume = "50",
pages = "435--442",
journal = "Archiv fur Geschwulstforschung",
issn = "0003-911X",
number = "5",

}

TY - JOUR

T1 - Cytochemical study of peritoneal macrophages in carrageenan-treated immunosuppressed mice

AU - Lapis, K.

AU - Tímár, J.

AU - Bencsath, M.

AU - Van Hanh, T.

AU - Kópper, L.

PY - 1980

Y1 - 1980

N2 - In our examinations the cytochemical characters of the peritoneal macrophages of immunosuppressed mice (Is-PM) were studied. It was stated that the acid phosphatase activity of their lysosomal system decreased in comparison to control cells (N-PM). In Is-PM cells the polyanion content of the cell-coat and the expression of their Con-A receptors decreased, while the glycos- and galactosaminoglycan (GAG) content showed a decrease on the surface of every cell of the population. On the first day following carrageenan treatment, acid phosphatase activity of the cells was very low, the GAG content and the conA receptors of the cell-coat disappeared. The characteristic lysosomal alterations could still be observed on the 6th day after treatment. On the basis of our observations, treatment with carrageenan impaired not only the lysosomal system of macrophages, but the cell surface too. These cytochemical changes may explain the dramatic decrease in macrophage function observed in carrageenan treatment.

AB - In our examinations the cytochemical characters of the peritoneal macrophages of immunosuppressed mice (Is-PM) were studied. It was stated that the acid phosphatase activity of their lysosomal system decreased in comparison to control cells (N-PM). In Is-PM cells the polyanion content of the cell-coat and the expression of their Con-A receptors decreased, while the glycos- and galactosaminoglycan (GAG) content showed a decrease on the surface of every cell of the population. On the first day following carrageenan treatment, acid phosphatase activity of the cells was very low, the GAG content and the conA receptors of the cell-coat disappeared. The characteristic lysosomal alterations could still be observed on the 6th day after treatment. On the basis of our observations, treatment with carrageenan impaired not only the lysosomal system of macrophages, but the cell surface too. These cytochemical changes may explain the dramatic decrease in macrophage function observed in carrageenan treatment.

UR - http://www.scopus.com/inward/record.url?scp=0019310412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019310412&partnerID=8YFLogxK

M3 - Article

C2 - 7458585

AN - SCOPUS:0019310412

VL - 50

SP - 435

EP - 442

JO - Archiv fur Geschwulstforschung

JF - Archiv fur Geschwulstforschung

SN - 0003-911X

IS - 5

ER -