Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids

H. S. Vargha, H. Medzihradszky-Schweiger, F. Ruff, K. Medzihrauszky

Research output: Article

5 Citations (Scopus)

Abstract

Intramolecular cyclization of the N - (2 - chloroethylcarbamoyl) derivatives of glycine, valine and phenylalanine give imidazolidone, oxazoline and hydantoin derivatives. The imidazolidone and oxazoline derivatives possess alkylating activity toward NBP. but the hydantoins do not. N - (2 - Chloroethylcarbamoyl)glycine reacts with the mercapto group of cysteine; thus, this alkylating group may be useful for receptor labelling.

Original languageEnglish
Pages (from-to)2255-2258
Number of pages4
JournalTetrahedron
Volume39
Issue number13
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Vargha, H. S., Medzihradszky-Schweiger, H., Ruff, F., & Medzihrauszky, K. (1983). Cyclization reactions of N-(2-chloroethylcarbamoyl) amino acids. Tetrahedron, 39(13), 2255-2258. https://doi.org/10.1016/S0040-4020(01)91949-0