Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation

H. Andrikovics, Zoltán Őrfi, Nóra Meggyesi, András Bors, Lívia Varga, Petra Kövy, Zsófia Vilimszky, Fanni Kolics, László Gopcsa, Péter Reményi, A. Tordai

Research output: Review article

1 Citation (Scopus)

Abstract

Primarily due to recent advances of detection techniques, microchimerism (the proportion of minor variant population is below 1%) has recently gained increasing attention in the field of transplantation. Availability of polymorphic markers, such as deletion insertion or single nucleotide polymorphisms along with a vast array of high sensitivity detection techniques, allow the accurate detection of small quantities of donor- or recipient-related materials. This diagnostic information can improve monitoring of allograft injuries in solid organ transplantations (SOT) as well as facilitate early detection of relapse in allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the present review, genetic marker and detection platform options applicable for microchimerism detection are discussed. Furthermore, current results of relevant clinical studies in the context of microchimerism and SOT or allo-HSCT respectively are also summarized.

Original languageEnglish
JournalInternational journal of molecular sciences
Volume20
Issue number18
DOIs
Publication statusPublished - szept. 10 2019

Fingerprint

Transplantation (surgical)
transplantation
Chimerism
Stem cells
Transplantation
Hematopoietic Stem Cell Transplantation
Organ Transplantation
trends
Nucleotides
Polymorphism
Allografts
stem cells
Availability
Genetic Markers
organs
markers
Single Nucleotide Polymorphism
Monitoring
Recurrence
deletion

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation. / Andrikovics, H.; Őrfi, Zoltán; Meggyesi, Nóra; Bors, András; Varga, Lívia; Kövy, Petra; Vilimszky, Zsófia; Kolics, Fanni; Gopcsa, László; Reményi, Péter; Tordai, A.

In: International journal of molecular sciences, Vol. 20, No. 18, 10.09.2019.

Research output: Review article

Andrikovics, H, Őrfi, Z, Meggyesi, N, Bors, A, Varga, L, Kövy, P, Vilimszky, Z, Kolics, F, Gopcsa, L, Reményi, P & Tordai, A 2019, 'Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation', International journal of molecular sciences, vol. 20, no. 18. https://doi.org/10.3390/ijms20184450
Andrikovics, H. ; Őrfi, Zoltán ; Meggyesi, Nóra ; Bors, András ; Varga, Lívia ; Kövy, Petra ; Vilimszky, Zsófia ; Kolics, Fanni ; Gopcsa, László ; Reményi, Péter ; Tordai, A. / Current Trends in Applications of Circulatory Microchimerism Detection in Transplantation. In: International journal of molecular sciences. 2019 ; Vol. 20, No. 18.
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