Magisztrális gyógyszerkészítmények minoségellenorzésének aktuális kérdé sei III. Teofillin tartalmú kúpok vizsgálata

Takácsné Novák Krisztina, Sinkó Bálint, Hang Ildikó, Kiss Gézáné, Dávid Ádám Zoltán, Horváth Péter

Research output: Article


In the present part of our series of papers a study on theophilline containing suppositories prepared in pharmacies is described. From the possible methods for assay of theophilline two nonaqueous titrations are compared. In first, theophilline is measured as a very weak base in a mixture of glacial acetic acid and acetic anhydride with perchloric acid using Sudan-III indicator, in second, the compound is measured as medium strong acid in dimethylformamide solvent with sodium-hydroxide titrant using phenolphtalein indicator. These methods were validated and the first was found more appropriate for regulatory controll. We investigated suppositories prepared in our laboratory and in different pharmacies. The study revealed the poor quality of the preparations due to the difficulties in the technology and the importance of the applied vehicle. A guideline for the good preparation practice and an alternative technology are proposed.

Translated title of the contributionCurrent problems in the quality controll of pharmaceutical preparations manufactured in pharmacies III. Investigation of theophilline containing suppositories
Original languageHungarian
Pages (from-to)82-89
Number of pages8
JournalActa pharmaceutica Hungarica
Issue number2
Publication statusPublished - aug. 24 2007

ASJC Scopus subject areas

  • Pharmaceutical Science

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