Current approaches to use cyclodextrins and mucoadhesive polymers in ocular drug delivery-a mini-review

Tivadar Bíró, Z. Aigner

Research output: Article

Abstract

Ocular drug delivery provides a challenging opportunity to develop optimal formulations with proper therapeutic effects and acceptable patient compliance because there are many restricting factors involved, such as complex anatomical structures, defensive mechanisms, rapid drainage, and applicability issues. Fortunately, recent advances in the field mean that these problems can be overcome through the formulation of innovative ophthalmic products. Through the addition of solubility enhancer cyclodextrin derivatives and mucoadhesive polymers, the permeability of active ingredients is improved, and retention time is increased in the ocular surface. Therefore, preferable efficacy and bioavailability can be achieved. In this short review, the authors describe the theoretical background, technological possibilities, and the current approaches in the field of ophthalmology.

Original languageEnglish
Article number15
JournalScientia Pharmaceutica
Volume87
Issue number3
DOIs
Publication statusPublished - szept. 1 2019

Fingerprint

Pharmaceutical Preparations
Cyclodextrins
Therapeutic Uses
Ophthalmology
Patient Compliance
Solubility
Biological Availability
Drainage
Permeability
Polymers
cyclodextrin polymer

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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