We have shown some important differences in the structure and function of the blood-brain barrier between young adult and aged male Wistar rats in our recent paper at Brain Research Bulletin (Bors et al., 2018). Among other data, we have presented two MR images about the brain of one representative young and one aged animals. The coronal sections of the brain at the level of caudate-putamen showed a significant dilation of both lateral and central (III-IV) cerebral ventricles and aqueduct (Figure 1). We concluded that this expansion of the ventricles can be the consequence of higher blood-brain barrier permeability with advanced age. [Figure presented] Figure 1. Comparison of anatomical structures of the brain in a coronal MR image of a young (left) and an aged (right) male Wistar rats. A strong hydrocephalus can be observed in the old animal. Young rat 2.5-month old, 269 g; aged rat 15.5-month old, 839 g. (After Bors et al., 2018) Some weeks ago we have finished a series of experiments in old Wistar rats and decided to perform MR imaging on the brain of the last three rats. The striatal sections (No 11-12-13-14) are presented in Figure 2. As it is observable the cerebral ventricles were not expanded at all in these animals, although the age of the rats was similar or even higher than that of the rat in our published experiment. Based on these new data we would like to modify our conclusion. The published enlarged ventricles in the old animal in our publication were exceptional and we can not generalize this finding in case of normal, healthy aging of Wistar rats. [Figure presented] Figure 2. Four consequtive coronal MRI sections of the brain of three aged male Wistar rats. The age and the body weights were as follows 1) 16 months, 530 g, 2) 21 months, 510 g, 3) 21 months, 588 g.
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