Correlations between clinicopathological parameters and molecular signatures of primary tumors for patients with stage T3N0 colorectal adenocarcinomas: A single center retrospective study on 100 cases

C. András, L. Tóth, Csaba Molnár, Miklós Tanyi, Zoltán Csiki, B. Dezső, János Pósán, Amir Houshang Shemirani, Emese Csiki, J. Szántó

Research output: Article

5 Citations (Scopus)

Abstract

Background/Aims: To examine the clinical and protein expression characteristics of tumor tissues for prediction of prognosis in colorectal cancer (CRC). Methodology: We retrospectively analyzed the clinicopathological data of patients with stage T3N0 CRC, operated between 1997-2003 and the surgical materials for the relation between disease prognosis and p53, p21, p16, β-catenin, E-cadherin, EGFR, hMLH1, hMSH2 and TS protein expressions. Results: A significantly shorter 3-year disease free survival was observed in patients under the age of 50. The worst 5-year overall survival (OS) observed for patients over 70. Tumor localization and number of processed lymph nodes significantly affected prognosis. The EGFR, hMSH2 and TS expressions and the 5-fluorouracyl treatment were not found to be of prognostic value; p53 and p21 positivity had significantly worse survival. When β-catenin membrane expression disappeared on tumor cells, the 5-year OS rate decreased and time to metastasis shortened significantly. Membrane β-catenin expression, processed lymph nodes number and age were detected as independent prognostic markers. Conclusions: These results suggest that the evaluation of a clinicopathological profile, based on age, tumor localization, number of examined lymph nodes, p53, p21 and E-cadherin β-catenin expression appears to be useful in identifying high risk patients.

Original languageEnglish
Pages (from-to)1091-1097
Number of pages7
JournalHepato-Gastroenterology
Volume59
Issue number116
DOIs
Publication statusPublished - jún. 2012

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Catenins
Adenocarcinoma
Retrospective Studies
Lymph Nodes
Cadherins
Colorectal Neoplasms
Neoplasms
Membranes
Survival
Disease-Free Survival
Proteins
Survival Rate
Neoplasm Metastasis
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

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title = "Correlations between clinicopathological parameters and molecular signatures of primary tumors for patients with stage T3N0 colorectal adenocarcinomas: A single center retrospective study on 100 cases",
abstract = "Background/Aims: To examine the clinical and protein expression characteristics of tumor tissues for prediction of prognosis in colorectal cancer (CRC). Methodology: We retrospectively analyzed the clinicopathological data of patients with stage T3N0 CRC, operated between 1997-2003 and the surgical materials for the relation between disease prognosis and p53, p21, p16, β-catenin, E-cadherin, EGFR, hMLH1, hMSH2 and TS protein expressions. Results: A significantly shorter 3-year disease free survival was observed in patients under the age of 50. The worst 5-year overall survival (OS) observed for patients over 70. Tumor localization and number of processed lymph nodes significantly affected prognosis. The EGFR, hMSH2 and TS expressions and the 5-fluorouracyl treatment were not found to be of prognostic value; p53 and p21 positivity had significantly worse survival. When β-catenin membrane expression disappeared on tumor cells, the 5-year OS rate decreased and time to metastasis shortened significantly. Membrane β-catenin expression, processed lymph nodes number and age were detected as independent prognostic markers. Conclusions: These results suggest that the evaluation of a clinicopathological profile, based on age, tumor localization, number of examined lymph nodes, p53, p21 and E-cadherin β-catenin expression appears to be useful in identifying high risk patients.",
keywords = "Colorectal cancer, Metastasis, Prognostic markers, TMA",
author = "C. Andr{\'a}s and L. T{\'o}th and Csaba Moln{\'a}r and Mikl{\'o}s Tanyi and Zolt{\'a}n Csiki and B. Dezső and J{\'a}nos P{\'o}s{\'a}n and Shemirani, {Amir Houshang} and Emese Csiki and J. Sz{\'a}nt{\'o}",
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TY - JOUR

T1 - Correlations between clinicopathological parameters and molecular signatures of primary tumors for patients with stage T3N0 colorectal adenocarcinomas

T2 - A single center retrospective study on 100 cases

AU - András, C.

AU - Tóth, L.

AU - Molnár, Csaba

AU - Tanyi, Miklós

AU - Csiki, Zoltán

AU - Dezső, B.

AU - Pósán, János

AU - Shemirani, Amir Houshang

AU - Csiki, Emese

AU - Szántó, J.

PY - 2012/6

Y1 - 2012/6

N2 - Background/Aims: To examine the clinical and protein expression characteristics of tumor tissues for prediction of prognosis in colorectal cancer (CRC). Methodology: We retrospectively analyzed the clinicopathological data of patients with stage T3N0 CRC, operated between 1997-2003 and the surgical materials for the relation between disease prognosis and p53, p21, p16, β-catenin, E-cadherin, EGFR, hMLH1, hMSH2 and TS protein expressions. Results: A significantly shorter 3-year disease free survival was observed in patients under the age of 50. The worst 5-year overall survival (OS) observed for patients over 70. Tumor localization and number of processed lymph nodes significantly affected prognosis. The EGFR, hMSH2 and TS expressions and the 5-fluorouracyl treatment were not found to be of prognostic value; p53 and p21 positivity had significantly worse survival. When β-catenin membrane expression disappeared on tumor cells, the 5-year OS rate decreased and time to metastasis shortened significantly. Membrane β-catenin expression, processed lymph nodes number and age were detected as independent prognostic markers. Conclusions: These results suggest that the evaluation of a clinicopathological profile, based on age, tumor localization, number of examined lymph nodes, p53, p21 and E-cadherin β-catenin expression appears to be useful in identifying high risk patients.

AB - Background/Aims: To examine the clinical and protein expression characteristics of tumor tissues for prediction of prognosis in colorectal cancer (CRC). Methodology: We retrospectively analyzed the clinicopathological data of patients with stage T3N0 CRC, operated between 1997-2003 and the surgical materials for the relation between disease prognosis and p53, p21, p16, β-catenin, E-cadherin, EGFR, hMLH1, hMSH2 and TS protein expressions. Results: A significantly shorter 3-year disease free survival was observed in patients under the age of 50. The worst 5-year overall survival (OS) observed for patients over 70. Tumor localization and number of processed lymph nodes significantly affected prognosis. The EGFR, hMSH2 and TS expressions and the 5-fluorouracyl treatment were not found to be of prognostic value; p53 and p21 positivity had significantly worse survival. When β-catenin membrane expression disappeared on tumor cells, the 5-year OS rate decreased and time to metastasis shortened significantly. Membrane β-catenin expression, processed lymph nodes number and age were detected as independent prognostic markers. Conclusions: These results suggest that the evaluation of a clinicopathological profile, based on age, tumor localization, number of examined lymph nodes, p53, p21 and E-cadherin β-catenin expression appears to be useful in identifying high risk patients.

KW - Colorectal cancer

KW - Metastasis

KW - Prognostic markers

KW - TMA

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