Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures

Dániel Veréb, Nikoletta Szabó, Bernadett Tuka, J. Tajti, András Király, Péter Faragó, Krisztián Kocsis, Eszter Tóth, Bálint Kincses, Teréz Bagoly, Z. Helyes, L. Vécsei, Zsigmond Tamás Kincses

Research output: Article

1 Citation (Scopus)

Abstract

OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.

Original languageEnglish
Pages (from-to)e1166-e1174
JournalNeurology
Volume91
Issue number12
DOIs
Publication statusPublished - szept. 18 2018

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Pituitary Adenylate Cyclase-Activating Polypeptide
Migraine Disorders
Adenylyl Cyclases
Peptides
Diffusion Tensor Imaging
Corpus Callosum
Anisotropy
Thalamus
Radioimmunoassay
Magnetic Resonance Spectroscopy
Software
Biomarkers
Radiation
Research
White Matter

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Veréb, D., Szabó, N., Tuka, B., Tajti, J., Király, A., Faragó, P., ... Kincses, Z. T. (2018). Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures. Neurology, 91(12), e1166-e1174. https://doi.org/10.1212/WNL.0000000000006201

Correlation of neurochemical and imaging markers in migraine : PACAP38 and DTI measures. / Veréb, Dániel; Szabó, Nikoletta; Tuka, Bernadett; Tajti, J.; Király, András; Faragó, Péter; Kocsis, Krisztián; Tóth, Eszter; Kincses, Bálint; Bagoly, Teréz; Helyes, Z.; Vécsei, L.; Kincses, Zsigmond Tamás.

In: Neurology, Vol. 91, No. 12, 18.09.2018, p. e1166-e1174.

Research output: Article

Veréb, D, Szabó, N, Tuka, B, Tajti, J, Király, A, Faragó, P, Kocsis, K, Tóth, E, Kincses, B, Bagoly, T, Helyes, Z, Vécsei, L & Kincses, ZT 2018, 'Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures', Neurology, vol. 91, no. 12, pp. e1166-e1174. https://doi.org/10.1212/WNL.0000000000006201
Veréb, Dániel ; Szabó, Nikoletta ; Tuka, Bernadett ; Tajti, J. ; Király, András ; Faragó, Péter ; Kocsis, Krisztián ; Tóth, Eszter ; Kincses, Bálint ; Bagoly, Teréz ; Helyes, Z. ; Vécsei, L. ; Kincses, Zsigmond Tamás. / Correlation of neurochemical and imaging markers in migraine : PACAP38 and DTI measures. In: Neurology. 2018 ; Vol. 91, No. 12. pp. e1166-e1174.
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abstract = "OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.",
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T1 - Correlation of neurochemical and imaging markers in migraine

T2 - PACAP38 and DTI measures

AU - Veréb, Dániel

AU - Szabó, Nikoletta

AU - Tuka, Bernadett

AU - Tajti, J.

AU - Király, András

AU - Faragó, Péter

AU - Kocsis, Krisztián

AU - Tóth, Eszter

AU - Kincses, Bálint

AU - Bagoly, Teréz

AU - Helyes, Z.

AU - Vécsei, L.

AU - Kincses, Zsigmond Tamás

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N2 - OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.

AB - OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.

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