Adatok a HLA antigének és az idiopathiás haemochromatosis hazai kapcsolatához.

E. Czink, E. Gyódi, K. Német, Z. Hollán

Research output: Review article

Abstract

The aim of our present work was to collect data on HLA distribution in patients with idiopathic haemochromatosis in Hungary. Ten unrelated patients with idiopathic haemochromatosis (6 men, 4 women) were studied. Idiopathic haemochromatosis was diagnosed on clinical, biochemical and histological grounds. HLA typing was performed in 10 probands and in all of their first degree relatives available (24) through 7 pedigree studies. HLA A3 was present in 6 of 10 probands [6/10 vs. 18.8% in the group of healthy blood donors (No 53) and 22.4% in Hungarian population (No 1910]. HLA B7 was present in 4 of 10 probands (40% vs. 11.3% and 14.6%). A3B7 antigen association has been found in 4 of 10 patients. A3B7 and A2B38 haplotypes were present twice in 4 of 7 genotyped probands. Pedigree studies revealed one nonaffected homozygote, 17 heterozygotes and 6 non carriers. Extended family and population studies are necessary to establish the gene frequency in Hungary and the probability of the involved haplotypes other than A3B7.

Translated title of the contributionCorrelation of HLA antigens and idiopathic hemochromatosis in Hungary
Original languageHungarian
Pages (from-to)409-410, 413-415
JournalOrvosi hetilap
Volume132
Issue number8
Publication statusPublished - febr. 24 1991

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Czink, E., Gyódi, E., Német, K., & Hollán, Z. (1991). Adatok a HLA antigének és az idiopathiás haemochromatosis hazai kapcsolatához. Orvosi hetilap, 132(8), 409-410, 413-415.