Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy

Kázmér Karádi, J. Janszky, Csilla Gyimesi, Zsolt Horváth, Tivadar Lucza, T. Dóczi, János Kállai, H. Ábrahám

Research output: Article

13 Citations (Scopus)

Abstract

Calbindin expression of granule cells of the dentate gyrus is decreased in temporal lobe epilepsy (TLE) regardless of its etiology. In this study, we examined the relation between reduction of calbindin immunoreactivity and the verbal and visuo-spatial memory function of patients with TLE of different etiologies. Significant linear correlation was shown between calbindin expression and short-term and long-term percent retention and retroactive interference in auditory verbal learning test (AVLT) of patients including those with hippocampal sclerosis. In addition, we found significant linear regression between calbindin expression and short-term and long-term percent retention of AVLT in patients whose epilepsy was caused by malformation of cortical development or tumor and when no hippocampal sclerosis and substantial neuronal loss were detected. Together with the role of calbindin in memory established in previous studies on calbindin knock-out mice, our results suggest that reduction of calbindin expression may contribute to memory impairments of patients with TLE, particularly, when neuronal loss is not significant.

Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalEpilepsy and Behavior
Volume25
Issue number1
DOIs
Publication statusPublished - szept. 2012

Fingerprint

Calbindins
Parahippocampal Gyrus
Temporal Lobe Epilepsy
Dentate Gyrus
Verbal Learning
Sclerosis
Malformations of Cortical Development
Knockout Mice
Linear Models
Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy. / Karádi, Kázmér; Janszky, J.; Gyimesi, Csilla; Horváth, Zsolt; Lucza, Tivadar; Dóczi, T.; Kállai, János; Ábrahám, H.

In: Epilepsy and Behavior, Vol. 25, No. 1, 09.2012, p. 110-119.

Research output: Article

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