Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

Attila Balogh, András Domokos, Balázs Farkas, Attila Farkas, Zsolt Rapi, Domokos Kiss, Zoltán Nyiri, Zsuzsanna Eke, Györgyi Szarka, Róbert Örkényi, Béla Mátravölgyi, Ferenc Faigl, György Marosi, Zsombor Kristóf Nagy

Research output: Article

26 Citations (Scopus)


Based on the concept of continuous manufacturing an end-to-end benchtop device was developed unprecedented for the production of solid drug dosage forms by connecting flow synthesis and formulation via electrospinning (ES). Together with the optimized two-step continuous-flow synthesis of acetylsalicylic acid (ASA) a water-soluble polymeric excipient (polyvinylpyrrolidone K30, PVPK30) was introduced. The resulting polymeric solution could be readily electrospun into solid nanofibers with high purity in one single step due to the excellent yet gentle drying effect of ES. The ASA-loaded fibers were electrostatically deposited onto a water-soluble pullulan sheet and the obtained double-layered films were continuously cut into orally dissolving webs (ODWs) as final dosage formulation. The synthesis as well as the dosing of the fibrous films were monitored by Process Analytical Technology (PAT) tools (IR and Raman spectroscopy) with active feedback on product quality. The successful coupling of flow synthesis and fiber formation confirms that ES enables versatile formulation of pharmaceuticals in future continuous production systems.

Original languageEnglish
Pages (from-to)290-299
Number of pages10
JournalChemical engineering journal
Publication statusPublished - okt. 15 2018


ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

Cite this

Balogh, A., Domokos, A., Farkas, B., Farkas, A., Rapi, Z., Kiss, D., Nyiri, Z., Eke, Z., Szarka, G., Örkényi, R., Mátravölgyi, B., Faigl, F., Marosi, G., & Nagy, Z. K. (2018). Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning. Chemical engineering journal, 350, 290-299.