Complete Clinical Remission of Stage IV Triple-Negative Breast Cancer Lung Metastasis Administering Low-Dose Immune Checkpoint Blockade in Combination With Hyperthermia and Interleukin-2

Ralf Kleef, Ralph Moss, A. Szász, Arthur Bohdjalian, Hans Bojar, Tibor Bakacs

Research output: Article

7 Citations (Scopus)


The prognosis of triple-negative breast cancer with metastases after chemotherapy remains dismal. We report the case of a 50-year-old female with first disease recurrence at the axillary lymph node and, later on, bilateral pulmonary metastases with severe shortness of breath. The patient received low-dose immune checkpoint blockade (concurrent nivolumab and ipilimumab) weekly over 3 weeks with regional hyperthermia 3 times a week, followed by systemic fever-range hyperthermia induced by interleukin-2 for 5 days. She went into complete remission of her pulmonary metastases with transient WHO I-II diarrhea and skin rash. The patient remained alive for 27 months after the start of treatment, with recurrence of metastases as a sternal mass, and up to 3 cm pleural metastases. This exceptional response should instigate further research efforts with this protocol, which consists only of approved drugs and treatments.

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalIntegrative Cancer Therapies
Issue number4
Publication statusPublished - dec. 1 2018


ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine

Cite this