Comparison of dihydrodiazepam enantiomers: Metabolism, serum binding and brain receptor binding

Zs Tegyey, G. Maksay, J. Kardos, L. Ötvös

Research output: Article

6 Citations (Scopus)

Abstract

Dihydrodiazepam is a diazepam prodrug, as shown by its in vitro metabolism by rat and mouse liver and brain microsomal fractions, and its displacing activity on brain diazepam binding. The mechanism of bioactivation is discussed. Stereoselectivity of metabolism and of binding to specific benzodiazepine binding sites in brain synpatosomes and serum albumin were studied.

Original languageEnglish
Pages (from-to)1031-1032
Number of pages2
JournalExperientia
Volume36
Issue number9
DOIs
Publication statusPublished - szept. 1980

Fingerprint

Enantiomers
Metabolism
Brain
Diazepam
Serum
Stereoselectivity
Prodrugs
Benzodiazepines
Serum Albumin
Liver
Rats
Binding Sites

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Comparison of dihydrodiazepam enantiomers : Metabolism, serum binding and brain receptor binding. / Tegyey, Zs; Maksay, G.; Kardos, J.; Ötvös, L.

In: Experientia, Vol. 36, No. 9, 09.1980, p. 1031-1032.

Research output: Article

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