Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity

Judit Denes, Adrienn Zsippai, Laszlo Kovacs, Zoltan Gorombey, Gabor L. Kovacs, M. Góth, P. Igaz, Erika Hubina

Research output: Article

Abstract

INTRODUCTION: Dysregulation of adipokine secretion and action is a characteristic feature of obesity and a key clinical feature of Cushing's syndrome (CS). We have investigated whether endogenous glucocorticoid excess influences adipose tissue-derived gene expression. MATERIAL AND METHODS: mRNA expression of adipokines; adiponectin, resistin, tumour necrosis factor-a, interleukin-6 (IL-6), angiotensinogen (AGT), plasminogen activator inhibitor type 1, retinol binding protein 4, visfatin, and cystatin C was assessed by quantitative real-time RT-PCR in visceral adipose tissue removed during abdominal surgery of eight patients with CS, and six control patients. RESULTS: We did not find any significant difference in the investigated genes; however, the almost significant overexpression of AGT and underexpression of IL-6 might be noteworthy (p = 0.06 in both cases). CONCLUSIONS: No significant differences were found in the expression of the investigated genes known as cardiometabolic risk factors. This indicates that there are no major differences between endogenous hypercortisolism or diet-induced obesity regarding the expression of adipokines involved in cardiometabolic disorders. However, the difference in AGT and IL-6 expression might be included in pathways affecting fat distribution in CS.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalEndokrynologia Polska
Volume70
Issue number2
DOIs
Publication statusPublished - jan. 1 2019

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Cushing Syndrome
Angiotensinogen
Adipokines
Adipose Tissue
Obesity
Diet
Interleukin-6
Genes
Cellular Retinol-Binding Proteins
Nicotinamide Phosphoribosyltransferase
Resistin
Gene Expression
Cystatin C
Plasminogen Inactivators
Intra-Abdominal Fat
Adiponectin
Glucocorticoids
Real-Time Polymerase Chain Reaction
Tumor Necrosis Factor-alpha
Fats

ASJC Scopus subject areas

  • Endocrinology

Cite this

Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity. / Denes, Judit; Zsippai, Adrienn; Kovacs, Laszlo; Gorombey, Zoltan; Kovacs, Gabor L.; Góth, M.; Igaz, P.; Hubina, Erika.

In: Endokrynologia Polska, Vol. 70, No. 2, 01.01.2019, p. 131-134.

Research output: Article

Denes, Judit ; Zsippai, Adrienn ; Kovacs, Laszlo ; Gorombey, Zoltan ; Kovacs, Gabor L. ; Góth, M. ; Igaz, P. ; Hubina, Erika. / Comparison of adipose tissue derived genes in endogenous Cushing's syndrome versus diet-induced obesity. In: Endokrynologia Polska. 2019 ; Vol. 70, No. 2. pp. 131-134.
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