Comparison between fixed-angle and customised corneal-polarisation compensation methods in scanning laser polarimetric measurement of the retinal nerve fibre layer in glaucoma

A. Katsanos, P. Kóthy, G. Holló

Research output: Article

5 Citations (Scopus)

Abstract

Purpose: To investigate the differences between the results of scanning laser polarimetric (SLP) measurements of the retinal nerve fibre layer thickness (RNFLT) made using two different corneal-polarisation techniques; customised (SLP-C), and fixed-angle (SLP-F) compensations. Methods: Both SLP-C and SLP-F were performed on 37 consecutive phakic patients with chronic open-angle glaucoma, and on 14 healthy control subjects. One randomly selected eye per subject was evaluated. Results: Both SLP-C and SLP-F parameters were able to discriminate between the glaucoma group and the control group, except in the case of the ellipse modulation, which differed significantly between the two groups with SLP-C (P = 0.017), but not with SLP-F (P = 0.056). When SLP-C and SLP-F values were compared, inferior maximum thickness and ellipse standard deviation were significantly lower with SLP-C in both groups (P <0.05 for each parameter). Superior maximum thickness was significantly lower in glaucoma with SLP-C than with SLP-F (P = 0.006) and tended to be lower with SLP-C than with SLP-F in the control group (P = 0.053). In the glaucoma group, it was only with SLP-C that a significant (positive) correlation between the superior maximum thickness and the inferior hemifield mean sensitivity (MS) (r = 0.653, P <0.001), and between the inferior maximum thickness and the superior hemifield MS (r = 0.420, P = 0.023) was found. The other global and sectoral SLP parameters showed significant correlation with the corresponding visual field parameters with both techniques. Conclusion: Our findings suggest that SLP measurements with customised compensation provide more realistic results for RNFLT than those made with the conventional fixed-angle compensation.

Original languageEnglish
Pages (from-to)152-158
Number of pages7
JournalEye
Volume19
Issue number2
DOIs
Publication statusPublished - febr. 2005

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Nerve Fibers
Glaucoma
Lasers
Control Groups
Open Angle Glaucoma
Visual Fields

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

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title = "Comparison between fixed-angle and customised corneal-polarisation compensation methods in scanning laser polarimetric measurement of the retinal nerve fibre layer in glaucoma",
abstract = "Purpose: To investigate the differences between the results of scanning laser polarimetric (SLP) measurements of the retinal nerve fibre layer thickness (RNFLT) made using two different corneal-polarisation techniques; customised (SLP-C), and fixed-angle (SLP-F) compensations. Methods: Both SLP-C and SLP-F were performed on 37 consecutive phakic patients with chronic open-angle glaucoma, and on 14 healthy control subjects. One randomly selected eye per subject was evaluated. Results: Both SLP-C and SLP-F parameters were able to discriminate between the glaucoma group and the control group, except in the case of the ellipse modulation, which differed significantly between the two groups with SLP-C (P = 0.017), but not with SLP-F (P = 0.056). When SLP-C and SLP-F values were compared, inferior maximum thickness and ellipse standard deviation were significantly lower with SLP-C in both groups (P <0.05 for each parameter). Superior maximum thickness was significantly lower in glaucoma with SLP-C than with SLP-F (P = 0.006) and tended to be lower with SLP-C than with SLP-F in the control group (P = 0.053). In the glaucoma group, it was only with SLP-C that a significant (positive) correlation between the superior maximum thickness and the inferior hemifield mean sensitivity (MS) (r = 0.653, P <0.001), and between the inferior maximum thickness and the superior hemifield MS (r = 0.420, P = 0.023) was found. The other global and sectoral SLP parameters showed significant correlation with the corresponding visual field parameters with both techniques. Conclusion: Our findings suggest that SLP measurements with customised compensation provide more realistic results for RNFLT than those made with the conventional fixed-angle compensation.",
keywords = "Customised corneal compensator, GDx, Glaucoma, Retinal nerve fibre layer thickness, Scanning laser polarimetry",
author = "A. Katsanos and P. K{\'o}thy and G. Holl{\'o}",
year = "2005",
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doi = "10.1038/sj.eye.6701429",
language = "English",
volume = "19",
pages = "152--158",
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T1 - Comparison between fixed-angle and customised corneal-polarisation compensation methods in scanning laser polarimetric measurement of the retinal nerve fibre layer in glaucoma

AU - Katsanos, A.

AU - Kóthy, P.

AU - Holló, G.

PY - 2005/2

Y1 - 2005/2

N2 - Purpose: To investigate the differences between the results of scanning laser polarimetric (SLP) measurements of the retinal nerve fibre layer thickness (RNFLT) made using two different corneal-polarisation techniques; customised (SLP-C), and fixed-angle (SLP-F) compensations. Methods: Both SLP-C and SLP-F were performed on 37 consecutive phakic patients with chronic open-angle glaucoma, and on 14 healthy control subjects. One randomly selected eye per subject was evaluated. Results: Both SLP-C and SLP-F parameters were able to discriminate between the glaucoma group and the control group, except in the case of the ellipse modulation, which differed significantly between the two groups with SLP-C (P = 0.017), but not with SLP-F (P = 0.056). When SLP-C and SLP-F values were compared, inferior maximum thickness and ellipse standard deviation were significantly lower with SLP-C in both groups (P <0.05 for each parameter). Superior maximum thickness was significantly lower in glaucoma with SLP-C than with SLP-F (P = 0.006) and tended to be lower with SLP-C than with SLP-F in the control group (P = 0.053). In the glaucoma group, it was only with SLP-C that a significant (positive) correlation between the superior maximum thickness and the inferior hemifield mean sensitivity (MS) (r = 0.653, P <0.001), and between the inferior maximum thickness and the superior hemifield MS (r = 0.420, P = 0.023) was found. The other global and sectoral SLP parameters showed significant correlation with the corresponding visual field parameters with both techniques. Conclusion: Our findings suggest that SLP measurements with customised compensation provide more realistic results for RNFLT than those made with the conventional fixed-angle compensation.

AB - Purpose: To investigate the differences between the results of scanning laser polarimetric (SLP) measurements of the retinal nerve fibre layer thickness (RNFLT) made using two different corneal-polarisation techniques; customised (SLP-C), and fixed-angle (SLP-F) compensations. Methods: Both SLP-C and SLP-F were performed on 37 consecutive phakic patients with chronic open-angle glaucoma, and on 14 healthy control subjects. One randomly selected eye per subject was evaluated. Results: Both SLP-C and SLP-F parameters were able to discriminate between the glaucoma group and the control group, except in the case of the ellipse modulation, which differed significantly between the two groups with SLP-C (P = 0.017), but not with SLP-F (P = 0.056). When SLP-C and SLP-F values were compared, inferior maximum thickness and ellipse standard deviation were significantly lower with SLP-C in both groups (P <0.05 for each parameter). Superior maximum thickness was significantly lower in glaucoma with SLP-C than with SLP-F (P = 0.006) and tended to be lower with SLP-C than with SLP-F in the control group (P = 0.053). In the glaucoma group, it was only with SLP-C that a significant (positive) correlation between the superior maximum thickness and the inferior hemifield mean sensitivity (MS) (r = 0.653, P <0.001), and between the inferior maximum thickness and the superior hemifield MS (r = 0.420, P = 0.023) was found. The other global and sectoral SLP parameters showed significant correlation with the corresponding visual field parameters with both techniques. Conclusion: Our findings suggest that SLP measurements with customised compensation provide more realistic results for RNFLT than those made with the conventional fixed-angle compensation.

KW - Customised corneal compensator

KW - GDx

KW - Glaucoma

KW - Retinal nerve fibre layer thickness

KW - Scanning laser polarimetry

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