Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone

János P. Mészáros, Jelena M. Poljarevic, G. Tamás Gál, Nóra V. May, G. Spengler, E. Enyedy

Research output: Article

Abstract

Half-sandwich organometallic complexes of curcumin are extensively investigated as anticancer compounds. Speciation studies were performed to explore the solution stability of curcumin complexes formed with [Rh(η 5 -C 5 Me 5 )(H 2 O) 3 ] 2+ . Acetylacetone (Hacac), as the simplest β-diketone ligand bearing (O,O) donor set, was involved for comparison and its Ru(η 6 ‑p‑cymene), Ru(η 6 ‑toluene) complexes were also studied. 1 H NMR, UV–visible and pH-potentiometric titrations revealed a clear trend of stability constants of the acac complexes: Ru(η 6 ‑p‑cymene) > Ru(η 6 ‑toluene) > Rh(η 5 -C 5 Me 5 ). Despite this order, the highest extent of complex formation is seen for the Rh(η 5 -C 5 Me 5 ) complexes at pH 7.4. Formation constant of [Rh(η 5 -C 5 Me 5 )(H 2 curcumin)(H 2 O)] + reveals similar solution stability to that of the acac complex. Additionally, structures of two complexes were determined by X-ray crystallography. The in vitro cytotoxicity of curcumin was not improved by the complexation with these organometallic cations.

Original languageEnglish
Pages (from-to)91-100
Number of pages10
JournalJournal of Inorganic Biochemistry
Volume195
DOIs
Publication statusPublished - jún. 1 2019

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Bearings (structural)
Rhodium
Curcumin
Ruthenium
Toluene
Organometallics
X ray crystallography
X Ray Crystallography
Cytotoxicity
Complexation
Titration
Cations
Nuclear magnetic resonance
Ligands
acetylacetone

Keywords

    ASJC Scopus subject areas

    • Biochemistry
    • Inorganic Chemistry

    Cite this

    Comparative solution and structural studies of half-sandwich rhodium and ruthenium complexes bearing curcumin and acetylacetone. / Mészáros, János P.; Poljarevic, Jelena M.; Gál, G. Tamás; May, Nóra V.; Spengler, G.; Enyedy, E.

    In: Journal of Inorganic Biochemistry, Vol. 195, 01.06.2019, p. 91-100.

    Research output: Article

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    AU - Mészáros, János P.

    AU - Poljarevic, Jelena M.

    AU - Gál, G. Tamás

    AU - May, Nóra V.

    AU - Spengler, G.

    AU - Enyedy, E.

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