A 2016-17-ben Magyarországon elôfordult magas patogenitásu H5N8 madárinf luenza összehasonlito patomorfológiája

Thuma Ákos, A. Dán, Rónai Zsuzsanna, Ursu Krisztina, K. Erdélyi, A. Bálint, Szalay Dóra, Gyuris Éva

Research output: Article

Abstract

Background: Highly pathogen avian influenza occurs from time to time in Hungary. The latest H5N8 outbreak during 2016-17 was especially devastating for the poultry industry. Objectives: The aim of this study is to summarize the comparative results of the pathomorphological examinations of infected birds during this outbreak, and also to provide up to date information for field veterinarians and poultry industry vets. Materials and Methods: Extensive pathological, histopathological and immu-nohistochemical examinations were carried out on H5N8 highly pathogenic avian influenza cases from each economically important poultry species that were submitted to our laboratory during the 2016-2017 outbreaks in Hungary. A range of organs was tested by PCR for HPAIV presence and sera of infected birds were tested by haemagglutination inhibition. Results and discussion: The involved H5N8 HPAI strain caused a disease with pronounced pathological lesions in waterfowl (goose, duck) and poor pathological lesions in gallinaceous birds (hen, Turkey). The brain lesions related to viral infection were found in every species by histopathological examination and the specific virus protein was detected by immunohistochemistry. Microscopic lesions in the liver and pancreas were of major significance in the post mortem diagnostics of the disease in waterfowl. Viral nucleic acid was detected in every organ examined, but serological examinations yielded negative results in every case as expected. In summary, although the ultimate diagnosis of avian influenza should be based on direct detection of the virus, pathomorphological knowledge of the disease is essential in both field and laboratory diagnostics.

Original languageHungarian
Pages (from-to)163-170
Number of pages8
JournalMagyar Allatorvosok Lapja
Volume141
Issue number3
Publication statusPublished - márc. 1 2019

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Influenza in Birds
Hungary
avian influenza
Poultry
lesions (animal)
Birds
Disease Outbreaks
poultry industry
Industry
waterfowl
Infection
infection
Viruses
Geese
birds
Ducks
Veterinarians
Hemagglutination
Virus Diseases
Turkey

ASJC Scopus subject areas

  • veterinary(all)

Cite this

A 2016-17-ben Magyarországon elôfordult magas patogenitásu H5N8 madárinf luenza összehasonlito patomorfológiája. / Ákos, Thuma; Dán, A.; Zsuzsanna, Rónai; Krisztina, Ursu; Erdélyi, K.; Bálint, A.; Dóra, Szalay; Éva, Gyuris.

In: Magyar Allatorvosok Lapja, Vol. 141, No. 3, 01.03.2019, p. 163-170.

Research output: Article

Ákos, Thuma ; Dán, A. ; Zsuzsanna, Rónai ; Krisztina, Ursu ; Erdélyi, K. ; Bálint, A. ; Dóra, Szalay ; Éva, Gyuris. / A 2016-17-ben Magyarországon elôfordult magas patogenitásu H5N8 madárinf luenza összehasonlito patomorfológiája. In: Magyar Allatorvosok Lapja. 2019 ; Vol. 141, No. 3. pp. 163-170.
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abstract = "Background: Highly pathogen avian influenza occurs from time to time in Hungary. The latest H5N8 outbreak during 2016-17 was especially devastating for the poultry industry. Objectives: The aim of this study is to summarize the comparative results of the pathomorphological examinations of infected birds during this outbreak, and also to provide up to date information for field veterinarians and poultry industry vets. Materials and Methods: Extensive pathological, histopathological and immu-nohistochemical examinations were carried out on H5N8 highly pathogenic avian influenza cases from each economically important poultry species that were submitted to our laboratory during the 2016-2017 outbreaks in Hungary. A range of organs was tested by PCR for HPAIV presence and sera of infected birds were tested by haemagglutination inhibition. Results and discussion: The involved H5N8 HPAI strain caused a disease with pronounced pathological lesions in waterfowl (goose, duck) and poor pathological lesions in gallinaceous birds (hen, Turkey). The brain lesions related to viral infection were found in every species by histopathological examination and the specific virus protein was detected by immunohistochemistry. Microscopic lesions in the liver and pancreas were of major significance in the post mortem diagnostics of the disease in waterfowl. Viral nucleic acid was detected in every organ examined, but serological examinations yielded negative results in every case as expected. In summary, although the ultimate diagnosis of avian influenza should be based on direct detection of the virus, pathomorphological knowledge of the disease is essential in both field and laboratory diagnostics.",
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AU - Dán, A.

AU - Zsuzsanna, Rónai

AU - Krisztina, Ursu

AU - Erdélyi, K.

AU - Bálint, A.

AU - Dóra, Szalay

AU - Éva, Gyuris

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