Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses

K. Rona, B. Gachalyi, L. Vereczkey, B. Nadas, A. Kaldor

Research output: Article

5 Citations (Scopus)

Abstract

Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance was investigated in a cross-over study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, V(d), AUD, t( 1/2 )) indicating that the two preparations are bioequivalent.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume25
Issue number9
Publication statusPublished - 1987

Fingerprint

Methyldopa
Biological Availability
Fluorometry
Pharmacokinetics
Hungary
Liver
Cross-Over Studies
Tablets
Hypertension
Kidney
Plasmas
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

Cite this

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abstract = "Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance was investigated in a cross-over study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, V(d), AUD, t( 1/2 )) indicating that the two preparations are bioequivalent.",
author = "K. Rona and B. Gachalyi and L. Vereczkey and B. Nadas and A. Kaldor",
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T1 - Comparative bioavailability study of two preparations of alpha-methyldopa after single, oral doses

AU - Rona, K.

AU - Gachalyi, B.

AU - Vereczkey, L.

AU - Nadas, B.

AU - Kaldor, A.

PY - 1987

Y1 - 1987

N2 - Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance was investigated in a cross-over study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, V(d), AUD, t( 1/2 )) indicating that the two preparations are bioequivalent.

AB - Bioavailability of alpha-methyldopa from a film coated tablet Dopegyt (EGIS Pharmaceutical Works, Budapest, Hungary) and from Aldometil (MSD, Sharp and Dohme GmbH, Munich, FRG) containing 250 mg of effective substance was investigated in a cross-over study in six patients with mild hypertension having normal renal and liver functions. Alpha-methyldopa was determined in plasma by fluorometry. There was no difference in the pharmacokinetic parameters calculated (Cl, V(d), AUD, t( 1/2 )) indicating that the two preparations are bioequivalent.

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EP - 518

JO - International Journal of Clinical Pharmacology and Therapeutics

JF - International Journal of Clinical Pharmacology and Therapeutics

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