Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.

Denise L. Faustman, Simon D. Tran, Shohta Kodama, Beatrijs M. Lodde, Ildiko Szalayova, Sharon Key, Z. Tóth, Eva Mezey

Research output: Article

13 Citations (Scopus)

Abstract

Chong et al., Nishio et al., and Suri et al. (Reports, 24 March 2006, pp. 1774, 1775, and 1778) confirmed that treating nonobese diabetic (NOD) mice with an immune adjuvant and semisyngenic spleen cells can reverse the disease but found that spleen cells did not contribute to the observed recovery of pancreatic islets. We show that islet regeneration predominately originates from endogenous cells but that introduced spleen cells can also contribute to islet recovery.

Original languageEnglish
JournalScience
Volume314
Issue number5803
Publication statusPublished - nov. 24 2006

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Inbred NOD Mouse
Spleen
Islets of Langerhans
Regeneration

ASJC Scopus subject areas

  • General

Cite this

Faustman, D. L., Tran, S. D., Kodama, S., Lodde, B. M., Szalayova, I., Key, S., ... Mezey, E. (2006). Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. Science, 314(5803).

Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. / Faustman, Denise L.; Tran, Simon D.; Kodama, Shohta; Lodde, Beatrijs M.; Szalayova, Ildiko; Key, Sharon; Tóth, Z.; Mezey, Eva.

In: Science, Vol. 314, No. 5803, 24.11.2006.

Research output: Article

Faustman, DL, Tran, SD, Kodama, S, Lodde, BM, Szalayova, I, Key, S, Tóth, Z & Mezey, E 2006, 'Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice.', Science, vol. 314, no. 5803.
Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S et al. Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. Science. 2006 nov. 24;314(5803).
Faustman, Denise L. ; Tran, Simon D. ; Kodama, Shohta ; Lodde, Beatrijs M. ; Szalayova, Ildiko ; Key, Sharon ; Tóth, Z. ; Mezey, Eva. / Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. In: Science. 2006 ; Vol. 314, No. 5803.
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