Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: Follow-up of immunopathological and clinical effects

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Systemic sclerosis (SSc) is an autoimmune disease which involves the skin, as well as several internal organs. Most therapies available in this disease are symptomatic. Authors present a case of diffuse SSc with progressive disease not responding to currently available treatments. Therefore a 12-month protocol of repeated plasmapheresis and high-dose intravenous immunoglobulin treatment was administered with good clinical efficacy. Apart from monitoring the clinical symptoms throughout the treatment, authors also assessed a number of humoral and cellular immunolaboratory markers in order to obtain information on the immunomodulatory effects of this combined treatment in SSc.

Original languageEnglish
Pages (from-to)347-350
Number of pages4
JournalClinical rheumatology
Issue number3
Publication statusPublished - jan. 1 2009


ASJC Scopus subject areas

  • Rheumatology

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