Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats

Research output: Article

5 Citations (Scopus)

Abstract

Purpose: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Methods: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4 h after injection. The changes in SWDs were compared to the preceding 5-day average control level. Results: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. Conclusions: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalEpilepsy Research
Volume90
Issue number1-2
DOIs
Publication statusPublished - jún. 2010

Fingerprint

Clomipramine
Absence Epilepsy
Incidence
Injections

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

@article{acac0a54e8ed4235be87d3c477593c00,
title = "Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats",
abstract = "Purpose: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Methods: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4 h after injection. The changes in SWDs were compared to the preceding 5-day average control level. Results: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. Conclusions: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.",
keywords = "Absence epilepsy, Clomipramine, WAG/Rij rats",
author = "Z. Kov{\'a}cs and A. Czurk{\'o} and K. K{\'e}kesi and G. Juh{\'a}sz",
year = "2010",
month = "6",
doi = "10.1016/j.eplepsyres.2010.02.011",
language = "English",
volume = "90",
pages = "167--170",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats

AU - Kovács, Z.

AU - Czurkó, A.

AU - Kékesi, K.

AU - Juhász, G.

PY - 2010/6

Y1 - 2010/6

N2 - Purpose: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Methods: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4 h after injection. The changes in SWDs were compared to the preceding 5-day average control level. Results: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. Conclusions: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.

AB - Purpose: The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Methods: We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4 h after injection. The changes in SWDs were compared to the preceding 5-day average control level. Results: The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period. Conclusions: Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.

KW - Absence epilepsy

KW - Clomipramine

KW - WAG/Rij rats

UR - http://www.scopus.com/inward/record.url?scp=77953535855&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953535855&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2010.02.011

DO - 10.1016/j.eplepsyres.2010.02.011

M3 - Article

C2 - 20299188

AN - SCOPUS:77953535855

VL - 90

SP - 167

EP - 170

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 1-2

ER -