Klinikai tapasztalataink cutan mastocytosisban

Noémi Mihalik, Bernadett Hidvégi, Judit Hársing, Judit Várkonyi, Judit Csomor, Ilona Kovalszky, Márta Marschalkó, Sarolta Kárpáti

Research output: Article

4 Citations (Scopus)


Introduction: Mastocytosis is a clonal mast cell proliferative disease, devided into cutaneous and systemic forms. The characteristic symptoms are caused by neoplastic mast cell infiltrations in different organs and/or the release of mediators. Aim: The aim of the authors was to summarize their clinical observations in patients with mastocytosis. Method: 22 adult patients diagnosed consecutively with mastocytosis were enrolled in the study. Skin and bone marrow biopsies were taken to establish the diagnosis and perform c-KIT mutation (D816V) analysis. Results: One of the 22 patients had teleangiectasia macularis eruptiva perstans, while 20/22 patients had urticaria pigmentosa. All patients had cutaneous lesions. In 12 patients iliac crest biopsy was performed and 9 of them had bone marrow involvement, classified as indolent systemic mastocytosis. The c-kit mutation D816V was found in one subject both in skin and bone marrow samples. The patients were treated with antihistamine, PUVA, interferon-α or imatinib. Conclusions: The authors draw attention to this rare disease in order to help recognition of relevant signs and symptoms and establish an early diagnosis.

Translated title of the contributionClinical observations in cutan mastocytosis
Original languageHungarian
Pages (from-to)1469-1475
Number of pages7
JournalOrvosi hetilap
Issue number37
Publication statusPublished - szept. 1 2013


  • bone marrow
  • c-KIT
  • mastocytosis
  • skin
  • urticaria pigmentosa

ASJC Scopus subject areas

  • Medicine(all)

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    Mihalik, N., Hidvégi, B., Hársing, J., Várkonyi, J., Csomor, J., Kovalszky, I., Marschalkó, M., & Kárpáti, S. (2013). Klinikai tapasztalataink cutan mastocytosisban. Orvosi hetilap, 154(37), 1469-1475. https://doi.org/10.1556/OH.2013.29702