Clinical, histopathological, immunophenotypic and molecular analysis of 60 patients with cutaneous T-cell infiltrates with follow up of indeterminate cases to identify T-cell lymphoma

Nóra Erős, Zsuzsánna Károlyi, Márta Marschalkó, Sarolta Kárpáti, András Matolcsy

Research output: Article

5 Citations (Scopus)

Abstract

Diagnosis of primary cutaneous T-cell lymphomas, especially of mycosis fungoides could be difficult in early stage due to clinical and histopathological similarity to reactive inflammatory dermatoses. To assess diagnostic value of complex histological, immunophenotypic and T-cell receptor γ gene rearrangement analysis, skin biopsy specimen and peripheral blood samples of 60 patients with suspected cutaneous T-cell lymphoma were analyzed. Our results indicate clear distinction between reactive dermatoses (benign cases, n=31) and cutaneous T-cell lymphomas (lymphoma cases, n=17). As definite diagnosis was not obtained in a smaller group of patients (indeterminate cases, n=12), these patients were followed up. Repeated skin biopsy confirmed mycosis fungoides in 6/12 cases, however in 6/12 patients the diagnosis remained indeterminate. We concluded that careful and complex clinical follow up and repeated histopathological, immunophenotypic and molecular analysis is needed for an appropriate diagnosis in the assessment of early stage mycosis fungoides and uncertain clinical cases.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalPathology and Oncology Research
Volume14
Issue number1
DOIs
Publication statusPublished - márc. 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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