Clinical differences in patients with unilateral hippocampal sclerosis and unitemporal or bitemporal epileptiform discharges

J. Janszky, G. Rásonyi, Z. Clemens, R. Schulz, M. Hoppe, P. Barsi, A. Fogarasi, P. Halász, A. Ebner

Research output: Article

20 Citations (Scopus)

Abstract

Purpose: To investigate factors determining the presence of bilateral interictal epileptiform discharges (IEDs) in temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (HS). Methods: We analysed data of 243 TLE patients with unilateral HS who had long-term video-EEG. Eighty-one patients (33%) had bitemporal IEDs. Results: We categorised patients into a unilateral group (UG), a bilateral group (BG) according to presence of bitemporal IEDs. We found no difference between UG and BG regarding epilepsy duration, secondarily generalised seizures, and history of febrile seizures. Mean seizure frequency was significantly higher in the BG (UG: 7.7 ± 14.7 seizures/month; BG: 13 ± 35 seizures/month, P = 0.01). We found a significant correlation between late epilepsy onset and the presence of bitemporal IEDs. The mean age at epilepsy onset in UG was 10.1 ± 7.9 years, while in BG it was 13 ± 9.2 years (P = 0.02). Conclusions: The traditional concept of the evolution of mirror focus cannot apply for humans because the duration of epilepsy does not influence the evolution of bitemporal IEDs. Other factors, i.e. age at onset and seizure frequency may play a role in this process. The association between the higher seizure frequency and mirror foci indicates that the development of mirror focus depends on seizures and not on a progressive 'interictal' epileptogenesis.

Original languageEnglish
Pages (from-to)550-554
Number of pages5
JournalSeizure
Volume12
Issue number8
DOIs
Publication statusPublished - dec. 2003

Fingerprint

Sclerosis
Seizures
Epilepsy
Temporal Lobe Epilepsy
Age of Onset
Febrile Seizures
Electroencephalography

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Psychology(all)

Cite this

@article{1510fb9bda4d427f86f4958c91058378,
title = "Clinical differences in patients with unilateral hippocampal sclerosis and unitemporal or bitemporal epileptiform discharges",
abstract = "Purpose: To investigate factors determining the presence of bilateral interictal epileptiform discharges (IEDs) in temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (HS). Methods: We analysed data of 243 TLE patients with unilateral HS who had long-term video-EEG. Eighty-one patients (33{\%}) had bitemporal IEDs. Results: We categorised patients into a unilateral group (UG), a bilateral group (BG) according to presence of bitemporal IEDs. We found no difference between UG and BG regarding epilepsy duration, secondarily generalised seizures, and history of febrile seizures. Mean seizure frequency was significantly higher in the BG (UG: 7.7 ± 14.7 seizures/month; BG: 13 ± 35 seizures/month, P = 0.01). We found a significant correlation between late epilepsy onset and the presence of bitemporal IEDs. The mean age at epilepsy onset in UG was 10.1 ± 7.9 years, while in BG it was 13 ± 9.2 years (P = 0.02). Conclusions: The traditional concept of the evolution of mirror focus cannot apply for humans because the duration of epilepsy does not influence the evolution of bitemporal IEDs. Other factors, i.e. age at onset and seizure frequency may play a role in this process. The association between the higher seizure frequency and mirror foci indicates that the development of mirror focus depends on seizures and not on a progressive 'interictal' epileptogenesis.",
keywords = "Age at onset, Epilepsy duration, Hippocampal sclerosis, Mirror focus, Seizure frequency",
author = "J. Janszky and G. R{\'a}sonyi and Z. Clemens and R. Schulz and M. Hoppe and P. Barsi and A. Fogarasi and P. Hal{\'a}sz and A. Ebner",
year = "2003",
month = "12",
doi = "10.1016/S1059-1311(03)00069-4",
language = "English",
volume = "12",
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TY - JOUR

T1 - Clinical differences in patients with unilateral hippocampal sclerosis and unitemporal or bitemporal epileptiform discharges

AU - Janszky, J.

AU - Rásonyi, G.

AU - Clemens, Z.

AU - Schulz, R.

AU - Hoppe, M.

AU - Barsi, P.

AU - Fogarasi, A.

AU - Halász, P.

AU - Ebner, A.

PY - 2003/12

Y1 - 2003/12

N2 - Purpose: To investigate factors determining the presence of bilateral interictal epileptiform discharges (IEDs) in temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (HS). Methods: We analysed data of 243 TLE patients with unilateral HS who had long-term video-EEG. Eighty-one patients (33%) had bitemporal IEDs. Results: We categorised patients into a unilateral group (UG), a bilateral group (BG) according to presence of bitemporal IEDs. We found no difference between UG and BG regarding epilepsy duration, secondarily generalised seizures, and history of febrile seizures. Mean seizure frequency was significantly higher in the BG (UG: 7.7 ± 14.7 seizures/month; BG: 13 ± 35 seizures/month, P = 0.01). We found a significant correlation between late epilepsy onset and the presence of bitemporal IEDs. The mean age at epilepsy onset in UG was 10.1 ± 7.9 years, while in BG it was 13 ± 9.2 years (P = 0.02). Conclusions: The traditional concept of the evolution of mirror focus cannot apply for humans because the duration of epilepsy does not influence the evolution of bitemporal IEDs. Other factors, i.e. age at onset and seizure frequency may play a role in this process. The association between the higher seizure frequency and mirror foci indicates that the development of mirror focus depends on seizures and not on a progressive 'interictal' epileptogenesis.

AB - Purpose: To investigate factors determining the presence of bilateral interictal epileptiform discharges (IEDs) in temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (HS). Methods: We analysed data of 243 TLE patients with unilateral HS who had long-term video-EEG. Eighty-one patients (33%) had bitemporal IEDs. Results: We categorised patients into a unilateral group (UG), a bilateral group (BG) according to presence of bitemporal IEDs. We found no difference between UG and BG regarding epilepsy duration, secondarily generalised seizures, and history of febrile seizures. Mean seizure frequency was significantly higher in the BG (UG: 7.7 ± 14.7 seizures/month; BG: 13 ± 35 seizures/month, P = 0.01). We found a significant correlation between late epilepsy onset and the presence of bitemporal IEDs. The mean age at epilepsy onset in UG was 10.1 ± 7.9 years, while in BG it was 13 ± 9.2 years (P = 0.02). Conclusions: The traditional concept of the evolution of mirror focus cannot apply for humans because the duration of epilepsy does not influence the evolution of bitemporal IEDs. Other factors, i.e. age at onset and seizure frequency may play a role in this process. The association between the higher seizure frequency and mirror foci indicates that the development of mirror focus depends on seizures and not on a progressive 'interictal' epileptogenesis.

KW - Age at onset

KW - Epilepsy duration

KW - Hippocampal sclerosis

KW - Mirror focus

KW - Seizure frequency

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DO - 10.1016/S1059-1311(03)00069-4

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JO - Seizure : the journal of the British Epilepsy Association

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