Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients

P. Horváth, Z. Lázár, G. Gálffy, R. Puskás, L. Kunos, Gy Losonczy, M. Mészáros, D. Tárnoki, D. L. Tárnoki, A. Bikov

Research output: Article

1 Citation (Scopus)

Abstract

Purpose: Obstructive sleep apnea (OSA) is characterized by chronic intermittent hypoxia which induces inflammation in blood vessels leading to the development of cardiovascular comorbidities. Several studies implicated the role of P-selectin in vascular inflammation of OSA. P-selectin glycoprotein ligand 1 (PSGL-1) is the main activator for P-selectin and is involved in immune cell trafficking. However, PSGL-1 has not been analyzed in OSA. The aim of the study was to investigate plasma PSGL-1 and P-selectin levels to have a deeper understanding on their interaction in obstructive sleep apnea. Methods: Fifty-one untreated patients with OSA and 42 non-OSA controls were recruited. Plasma PSGL-1 levels were determined in evening and morning samples, P-selectin levels were analyzed in morning samples using commercially available ELISA kits. Polysomnography was performed in all participants. OSA was defined by an apnea–hypopnea index ≥ 5/h. Results: PSGL-1 levels did not differ between controls and OSA patients either in the evening or in the morning. Although, there was no difference between controls (16.9/6.8–40.8 ng/ml) and patients with OSA (19.6/8.4–56.8, p = 0.24), patients with severe OSA had increased plasma P-selectin levels (25.6/8.4–56.8 ng/ml) compared to mild OSA patients (14.1/8.5–35.3 ng/ml, p = 0.006) and controls (p = 0.03). Conclusions: P-selectin expression relates to disease severity suggesting a pathophysiological role in endothelial cell activation. PSGL-1 levels are unaltered in OSA, suggesting an alternative activation pathway for P-selectin in OSA.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalLung
Volume198
Issue number1
DOIs
Publication statusPublished - febr. 1 2020

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Horváth, P., Lázár, Z., Gálffy, G., Puskás, R., Kunos, L., Losonczy, G., Mészáros, M., Tárnoki, D., Tárnoki, D. L., & Bikov, A. (2020). Circulating P-Selectin Glycoprotein Ligand 1 and P-Selectin Levels in Obstructive Sleep Apnea Patients. Lung, 198(1), 173-179. https://doi.org/10.1007/s00408-019-00299-0