Chemokines and chemokine receptors in arthritis

Research output: Article

72 Citations (Scopus)

Abstract

Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.

Original languageEnglish
Pages (from-to)153-167
Number of pages15
JournalFrontiers in Bioscience - Scholar
Volume2 S
Issue number1
Publication statusPublished - jan. 1 2010

Fingerprint

Chemokine Receptors
Chemokines
Arthritis
Rheumatoid Arthritis
CX3C Chemokines
C Chemokines
CXC Chemokines
CC Chemokines
Biological Therapy
Animals
Leukocytes
Animal Models
Tissue

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Chemokines and chemokine receptors in arthritis. / Szekanecz, Z.; Végvári, A.; Szabó, Z.; Koch, Alisa E.

In: Frontiers in Bioscience - Scholar, Vol. 2 S, No. 1, 01.01.2010, p. 153-167.

Research output: Article

@article{86face6f6f04410f9d6aee969aff6dc2,
title = "Chemokines and chemokine receptors in arthritis",
abstract = "Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.",
keywords = "Chemokine Receptors, Chemokines, Review, Rheumatoid Arthritis, Targeting",
author = "Z. Szekanecz and A. V{\'e}gv{\'a}ri and Z. Szab{\'o} and Koch, {Alisa E.}",
year = "2010",
month = "1",
day = "1",
language = "English",
volume = "2 S",
pages = "153--167",
journal = "Frontiers in Bioscience - Scholar",
issn = "1945-0516",
publisher = "Frontiers in Bioscience",
number = "1",

}

TY - JOUR

T1 - Chemokines and chemokine receptors in arthritis

AU - Szekanecz, Z.

AU - Végvári, A.

AU - Szabó, Z.

AU - Koch, Alisa E.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.

AB - Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.

KW - Chemokine Receptors

KW - Chemokines

KW - Review

KW - Rheumatoid Arthritis

KW - Targeting

UR - http://www.scopus.com/inward/record.url?scp=77957315892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957315892&partnerID=8YFLogxK

M3 - Article

VL - 2 S

SP - 153

EP - 167

JO - Frontiers in Bioscience - Scholar

JF - Frontiers in Bioscience - Scholar

SN - 1945-0516

IS - 1

ER -