Chemistry of indoles carrying a basic function. Part 8: A new approach to the ergoline skeleton

Mária Incze, István Moldvai, Eszter Temesvári-Major, Gábor Dörnyei, Mária Kajtár-Peredy, Csaba Szántay

Research output: Article

5 Citations (Scopus)

Abstract

Starting from N-pivaloyl-Uhle's ketone a new synthetic approach to the ergoline skeleton has been elaborated. Ring D of the tetracyclic skeleton was formed by an intramolecular Dieckmann-condensation of a diester, obtained in a Reformatsky reaction of a properly substituted derivative of N-pivaloyl Uhle's ketone followed by elimination of water.

Original languageEnglish
Pages (from-to)4281-4286
Number of pages6
JournalTetrahedron
Volume59
Issue number24
DOIs
Publication statusPublished - jún. 9 2003

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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