Charged single alpha-helices in proteomes revealed by a consensus prediction approach

Zoltán Gáspári, Dániel Süveges, András Perczel, László Nyitray, Gábor Tóth

Research output: Article

21 Citations (Scopus)

Abstract

Charged single α-helices (CSAHs) constitute a recently recognized protein structural motif. Its presence and role is characterized in only a few proteins. To explore its general features, a comprehensive study is necessary. We have set up a consensus prediction method available as a web service (at http://csahserver.chem.elte.hu) and downloadable scripts capable of predicting CSAHs from protein sequences. Using our method, we have performed a comprehensive search on the UniProt database. We found that the motif is very rare but seems abundant in proteins involved in symbiosis and RNA binding/processing. Although there are related proteins with CSAH segments, the motif shows no deep conservation in protein families. We conclude that CSAH-containing proteins, although rare, are involved in many key biological processes. Their conservation pattern and prevalence in symbiosis-associated proteins suggest that they might be subjects of relatively rapid molecular evolution and thus can contribute to the emergence of novel functions.

Original languageEnglish
Pages (from-to)637-646
Number of pages10
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1824
Issue number4
DOIs
Publication statusPublished - ápr. 1 2012

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

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