Charge-transfer chromatographic study on the inclusion complex formation of some barbituric acid derivatives with varrious cyclodextrins

T. Cserháti, J. Szejtli, J. Bojarski

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11 Citations (Scopus)

Abstract

The inclusion complexing capacity of 21 barbituric acid derivatives with α-, β- and γ-cyclodextrins, with a water soluble β-cyclodextrin polymer and with 2,6-di-O-methyl-β-cyclodextrin was determined by chargetransfer chromatography on reversed-phase thin-layer plates. It was established that 2,6-di-O-methyl-β-cyclodextrin formed the most stable complexes with the barbituric acid derivatives followed by the water soluble β-cyclodextrin polymer. The complex forming capacities of β- and γ-cyclodextrins were similar to each other while the α-cyclodextrin formed very weak complexes. Each cyclodextrin had a different sterical requirement of substituents of the barbituric acid derivatives to fit optimally into the cyclodextrin cavity.

Original languageEnglish
Pages (from-to)455-458
Number of pages4
JournalChromatographia
Volume28
Issue number9-10
DOIs
Publication statusPublished - nov. 1 1989

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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