Characterization of peak purity by fast multiscan circular dichroism detection

Research output: Article

7 Citations (Scopus)

Abstract

A method has been developed to detect inhomogeneity of apparently homogeneous peaks of very similar analytes. The method utilizes the rapid scan feature of state-of-the-art spectrometers/detectors that allow the recording of up to 30 spectra in a single chromatographic peak. Sensitivity and selectivity are enhanced by chiroptical/optical detection. Thus, identification of 'front' and 'rear' components of the peak can be carried out. The method is exemplified by mixtures of codeine, hydrocodone and oxycodone as analytes.

Original languageEnglish
Pages (from-to)584-588
Number of pages5
JournalChromatographia
Volume48
Issue number7-8
DOIs
Publication statusPublished - nov. 17 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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