Characterization of lactate-guanidinium and lactate-lactate interactions in aqueous solution by spectropolarimetry

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Abstract

Spectropolarimetry has been used to quantify the lactate-guanidinium and lactate-lactate equilibrium interactions in aqueous solution. Association constants for the lactate-guanidinium and lactate-lactate, formations are 6.11 dm3 mol-1 and 1.12 dm3 mol-1, respectively, in aqueous solution; 6.11 dm3 mol-1 is a high value for an electrostatic interaction in water. This stability, however, cannot account for the extremely strong lactate-protein binding, observed earlier by NMR spectroscopy. The molar rotation coefficients for both the heteroassociation and homoassociation complexes are also calculated. The homoassociative lactate-lactate binding is the first such interaction, whose constant has been determined by spectropolarimetry in aqueous solution.

Original languageEnglish
Pages (from-to)1419-1422
Number of pages4
JournalJournal of the Chemical Society. Perkin Transactions 2
Volume7
DOIs
Publication statusPublished - jan. 1 1996

ASJC Scopus subject areas

  • Chemistry(all)

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