Characterisation of a hydraulic high-pressure sample introduction assisted flow injection - Inductively coupled plasma time-of-flight mass spectrometry system and its application to the analysis of biological samples

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5 Citations (Scopus)

Abstract

A flow injection (FI) method was developed using hydraulic high-pressure nebulization as a sample introduction system, coupled to inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS) for rapid and simultaneous determination of 19 elements. The operating conditions of the system (analyte flow rate, heating and cooling temperatures of the desolvation module, carrier gas flow rate) for the simultaneous determination of 19 analytes were optimised. The optimum parameters of the sample introduction system were found to be 1.4 ml min-1 and 1.35 l min-1 for the analyte solution and nebulizer flow rates, respectively. A compromised condition for heating and cooling stage temperatures of 170 and -5°C was chosen. The detection limits were compared to those obtained by using ICP-TOFMS with alternative sample introduction techniques e.g. conventional nebulization, flow injection chemical hydride generation (FI-CHG) and the obtained results were comparable or better than those resulting from alternative sample introduction. Applying the optimised conditions the simultaneous determination of Ag, As, Ba, Cd, Co, Cu, Ga, In, Li, Mn, Mo, Pb, Sb, Se, Sn, Sr, Tl, V and Zn was carried out. Absolute detection limits (3σ) in the range of 2-750 pg and precision between 0.5 and 9.6% from five replicate measurements of 10 ng ml-1 multielemental sample solutions were achieved by using a 200 μl sample loop. The developed method was applied for the analysis of certified reference materials of biological origin (TORT-2 "Lobster Hepatopancrease", BCR-422 "Cod Muscle" and IAEA MA-B-3/TM "Fish Homogenate"), and the results showed good agreement with the certified values.

Original languageEnglish
Pages (from-to)705-712
Number of pages8
JournalTalanta
Volume63
Issue number3
DOIs
Publication statusPublished - jún. 17 2004

Fingerprint

Inductively coupled plasma
Heating
Mass spectrometry
Limit of Detection
Mass Spectrometry
Flow rate
Hydraulics
Mass spectrometers
Pressure
Gadiformes
Injections
Temperature
Nebulizers and Vaporizers
Cooling
Gases
Hydrides
Muscles
Fish
Flow of gases
Muscle

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

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title = "Characterisation of a hydraulic high-pressure sample introduction assisted flow injection - Inductively coupled plasma time-of-flight mass spectrometry system and its application to the analysis of biological samples",
abstract = "A flow injection (FI) method was developed using hydraulic high-pressure nebulization as a sample introduction system, coupled to inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS) for rapid and simultaneous determination of 19 elements. The operating conditions of the system (analyte flow rate, heating and cooling temperatures of the desolvation module, carrier gas flow rate) for the simultaneous determination of 19 analytes were optimised. The optimum parameters of the sample introduction system were found to be 1.4 ml min-1 and 1.35 l min-1 for the analyte solution and nebulizer flow rates, respectively. A compromised condition for heating and cooling stage temperatures of 170 and -5°C was chosen. The detection limits were compared to those obtained by using ICP-TOFMS with alternative sample introduction techniques e.g. conventional nebulization, flow injection chemical hydride generation (FI-CHG) and the obtained results were comparable or better than those resulting from alternative sample introduction. Applying the optimised conditions the simultaneous determination of Ag, As, Ba, Cd, Co, Cu, Ga, In, Li, Mn, Mo, Pb, Sb, Se, Sn, Sr, Tl, V and Zn was carried out. Absolute detection limits (3σ) in the range of 2-750 pg and precision between 0.5 and 9.6{\%} from five replicate measurements of 10 ng ml-1 multielemental sample solutions were achieved by using a 200 μl sample loop. The developed method was applied for the analysis of certified reference materials of biological origin (TORT-2 {"}Lobster Hepatopancrease{"}, BCR-422 {"}Cod Muscle{"} and IAEA MA-B-3/TM {"}Fish Homogenate{"}), and the results showed good agreement with the certified values.",
keywords = "Biological samples, Flow injection, Hydraulic high-pressure nebulizer, Inductively coupled plasma time-of-flight mass spectrometry",
author = "Z. Stef{\'a}nka and L. Abrank{\'o} and M. Dernovics and P. Fodor",
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doi = "10.1016/j.talanta.2003.12.019",
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T1 - Characterisation of a hydraulic high-pressure sample introduction assisted flow injection - Inductively coupled plasma time-of-flight mass spectrometry system and its application to the analysis of biological samples

AU - Stefánka, Z.

AU - Abrankó, L.

AU - Dernovics, M.

AU - Fodor, P.

PY - 2004/6/17

Y1 - 2004/6/17

N2 - A flow injection (FI) method was developed using hydraulic high-pressure nebulization as a sample introduction system, coupled to inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS) for rapid and simultaneous determination of 19 elements. The operating conditions of the system (analyte flow rate, heating and cooling temperatures of the desolvation module, carrier gas flow rate) for the simultaneous determination of 19 analytes were optimised. The optimum parameters of the sample introduction system were found to be 1.4 ml min-1 and 1.35 l min-1 for the analyte solution and nebulizer flow rates, respectively. A compromised condition for heating and cooling stage temperatures of 170 and -5°C was chosen. The detection limits were compared to those obtained by using ICP-TOFMS with alternative sample introduction techniques e.g. conventional nebulization, flow injection chemical hydride generation (FI-CHG) and the obtained results were comparable or better than those resulting from alternative sample introduction. Applying the optimised conditions the simultaneous determination of Ag, As, Ba, Cd, Co, Cu, Ga, In, Li, Mn, Mo, Pb, Sb, Se, Sn, Sr, Tl, V and Zn was carried out. Absolute detection limits (3σ) in the range of 2-750 pg and precision between 0.5 and 9.6% from five replicate measurements of 10 ng ml-1 multielemental sample solutions were achieved by using a 200 μl sample loop. The developed method was applied for the analysis of certified reference materials of biological origin (TORT-2 "Lobster Hepatopancrease", BCR-422 "Cod Muscle" and IAEA MA-B-3/TM "Fish Homogenate"), and the results showed good agreement with the certified values.

AB - A flow injection (FI) method was developed using hydraulic high-pressure nebulization as a sample introduction system, coupled to inductively coupled plasma time-of-flight mass spectrometer (ICP-TOFMS) for rapid and simultaneous determination of 19 elements. The operating conditions of the system (analyte flow rate, heating and cooling temperatures of the desolvation module, carrier gas flow rate) for the simultaneous determination of 19 analytes were optimised. The optimum parameters of the sample introduction system were found to be 1.4 ml min-1 and 1.35 l min-1 for the analyte solution and nebulizer flow rates, respectively. A compromised condition for heating and cooling stage temperatures of 170 and -5°C was chosen. The detection limits were compared to those obtained by using ICP-TOFMS with alternative sample introduction techniques e.g. conventional nebulization, flow injection chemical hydride generation (FI-CHG) and the obtained results were comparable or better than those resulting from alternative sample introduction. Applying the optimised conditions the simultaneous determination of Ag, As, Ba, Cd, Co, Cu, Ga, In, Li, Mn, Mo, Pb, Sb, Se, Sn, Sr, Tl, V and Zn was carried out. Absolute detection limits (3σ) in the range of 2-750 pg and precision between 0.5 and 9.6% from five replicate measurements of 10 ng ml-1 multielemental sample solutions were achieved by using a 200 μl sample loop. The developed method was applied for the analysis of certified reference materials of biological origin (TORT-2 "Lobster Hepatopancrease", BCR-422 "Cod Muscle" and IAEA MA-B-3/TM "Fish Homogenate"), and the results showed good agreement with the certified values.

KW - Biological samples

KW - Flow injection

KW - Hydraulic high-pressure nebulizer

KW - Inductively coupled plasma time-of-flight mass spectrometry

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