Chapter 18: The role of kynurenine pathway in pain and migraine

Zsófi A. Majláth, J. Toldi, L. Vécsei

Research output: Chapter

Abstract

Migraine is a highly prevalent, disabling primary headache disorder which has a high socioeconomic impact. Its pathomechanism involves peripheral and central sensitization processes and activation of the trigeminovascular system. Alterations in the glutamatergic neurotransmission and the activation of excitatory receptors leading to neuronal hyperexcitability have been implicated in the pathomechanism of different pain syndromes, including migraine and neuropathic pain. The pharmacological management of these disorders is often a challenge, and the identifi cation of possible new druggable targets is therefore at the focus of research interest. The kynurenine pathway involves several neuroactive metabolites which can infl uence glutamatergic neurotransmission and may therefore be promising novel candidates for drug development.

Original languageEnglish
Title of host publicationTargeting the Broadly Pathogenic Kynurenine Pathway
PublisherSpringer International Publishing
Pages233-240
Number of pages8
ISBN (Print)9783319118703, 9783319118697
DOIs
Publication statusPublished - jan. 1 2015

Fingerprint

Kynurenine
Migraine Disorders
Synaptic Transmission
Chemical activation
Primary Headache Disorders
Central Nervous System Sensitization
Pain
Neuralgia
Metabolites
Cations
Pharmacology
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Majláth, Z. A., Toldi, J., & Vécsei, L. (2015). Chapter 18: The role of kynurenine pathway in pain and migraine. In Targeting the Broadly Pathogenic Kynurenine Pathway (pp. 233-240). Springer International Publishing. https://doi.org/10.1007/978-3-319-11870-3_18

Chapter 18 : The role of kynurenine pathway in pain and migraine. / Majláth, Zsófi A.; Toldi, J.; Vécsei, L.

Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 2015. p. 233-240.

Research output: Chapter

Majláth, ZA, Toldi, J & Vécsei, L 2015, Chapter 18: The role of kynurenine pathway in pain and migraine. in Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, pp. 233-240. https://doi.org/10.1007/978-3-319-11870-3_18
Majláth ZA, Toldi J, Vécsei L. Chapter 18: The role of kynurenine pathway in pain and migraine. In Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing. 2015. p. 233-240 https://doi.org/10.1007/978-3-319-11870-3_18
Majláth, Zsófi A. ; Toldi, J. ; Vécsei, L. / Chapter 18 : The role of kynurenine pathway in pain and migraine. Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 2015. pp. 233-240
@inbook{1ef1c62e2c364cca8fd1a7e6f3b40b85,
title = "Chapter 18: The role of kynurenine pathway in pain and migraine",
abstract = "Migraine is a highly prevalent, disabling primary headache disorder which has a high socioeconomic impact. Its pathomechanism involves peripheral and central sensitization processes and activation of the trigeminovascular system. Alterations in the glutamatergic neurotransmission and the activation of excitatory receptors leading to neuronal hyperexcitability have been implicated in the pathomechanism of different pain syndromes, including migraine and neuropathic pain. The pharmacological management of these disorders is often a challenge, and the identifi cation of possible new druggable targets is therefore at the focus of research interest. The kynurenine pathway involves several neuroactive metabolites which can infl uence glutamatergic neurotransmission and may therefore be promising novel candidates for drug development.",
keywords = "Glutamate, Hyperexcitability, Kynurenic acid, Kynurenine pathway, Migraine, Neuropathic pain, Nociception",
author = "Majl{\'a}th, {Zs{\'o}fi A.} and J. Toldi and L. V{\'e}csei",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-11870-3_18",
language = "English",
isbn = "9783319118703",
pages = "233--240",
booktitle = "Targeting the Broadly Pathogenic Kynurenine Pathway",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Chapter 18

T2 - The role of kynurenine pathway in pain and migraine

AU - Majláth, Zsófi A.

AU - Toldi, J.

AU - Vécsei, L.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Migraine is a highly prevalent, disabling primary headache disorder which has a high socioeconomic impact. Its pathomechanism involves peripheral and central sensitization processes and activation of the trigeminovascular system. Alterations in the glutamatergic neurotransmission and the activation of excitatory receptors leading to neuronal hyperexcitability have been implicated in the pathomechanism of different pain syndromes, including migraine and neuropathic pain. The pharmacological management of these disorders is often a challenge, and the identifi cation of possible new druggable targets is therefore at the focus of research interest. The kynurenine pathway involves several neuroactive metabolites which can infl uence glutamatergic neurotransmission and may therefore be promising novel candidates for drug development.

AB - Migraine is a highly prevalent, disabling primary headache disorder which has a high socioeconomic impact. Its pathomechanism involves peripheral and central sensitization processes and activation of the trigeminovascular system. Alterations in the glutamatergic neurotransmission and the activation of excitatory receptors leading to neuronal hyperexcitability have been implicated in the pathomechanism of different pain syndromes, including migraine and neuropathic pain. The pharmacological management of these disorders is often a challenge, and the identifi cation of possible new druggable targets is therefore at the focus of research interest. The kynurenine pathway involves several neuroactive metabolites which can infl uence glutamatergic neurotransmission and may therefore be promising novel candidates for drug development.

KW - Glutamate

KW - Hyperexcitability

KW - Kynurenic acid

KW - Kynurenine pathway

KW - Migraine

KW - Neuropathic pain

KW - Nociception

UR - http://www.scopus.com/inward/record.url?scp=84957011604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957011604&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-11870-3_18

DO - 10.1007/978-3-319-11870-3_18

M3 - Chapter

AN - SCOPUS:84957011604

SN - 9783319118703

SN - 9783319118697

SP - 233

EP - 240

BT - Targeting the Broadly Pathogenic Kynurenine Pathway

PB - Springer International Publishing

ER -