Chaperones and aging: Role in neurodegeneration and in other civilizational diseases

Research output: Article

76 Citations (Scopus)

Abstract

Chaperones are highly conserved proteins responsible for the preservation and repair of the correct conformation of cellular macromolecules, such as proteins, RNAs, etc. Environmental stress leads to chaperone (heat-shock protein, stress protein) induction reflecting the protective role of chaperones as a key factor for cell survival and in repairing cellular damage after stress. The present review summarizes our current knowledge about the chaperone-deficiency in the aging process, as well as the possible involvement of chaperones in neurodegenerative diseases, such as in Alzheimer's, Parkinson's, Huntington- and prion-related diseases. We also summarize a recent theory implying chaperones as "buffers" of variations in the human genome, which role probably increased during the last 200 years of successful medical practice minimizing natural selection. Chaperone-buffered, silent mutations may be activated during the aging process, which leads to the phenotypic exposure of previously hidden features and might contribute to the onset of polygenic diseases, such as atherosclerosis, cancer, diabetes and several neurodegenerative diseases.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalNeurochemistry International
Volume41
Issue number6
DOIs
Publication statusPublished - dec. 2002

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Heat-Shock Proteins
Neurodegenerative Diseases
Prion Diseases
Genetic Selection
Human Genome
Cell Survival
Atherosclerosis
Buffers
Proteins
RNA
Neoplasms
Silent Mutation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

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