Changes in polysaccarides in bone and articular cartilage of rats exposed to fluoride

Research output: Article


Osteofluorosis was assessed experimentally by studying the changes in the capsular and intercapsular polysaccharides of the bone tissue and articular cartilage of rats exposed to sodium fluoride (0.5 mg and 5 mg administered daily for three months). The exposure markedly decreased the regular linear orientation of the polysaccharides. The disarray was associated with damage to the capsular and intercapsular proteoglycin aggregate matrix and collagen structure. These changes may be considered as manifestations of the toxic effects of fluoride.

Original languageEnglish
Number of pages1
Issue number3
Publication statusPublished - dec. 1 1996


ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Dentistry(all)
  • Toxicology
  • Agricultural and Biological Sciences(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this