Cerebrovascular involvement in liposome-induced cardiopulmonary distress in pigs

Michael Bodo, Janos Szebeni, Lajos Baranyi, Sandor Savay, Frederick J. Pearce, Carl R. Alving, Rolf Bünger

Research output: Article

11 Citations (Scopus)

Abstract

Intravenous administration of liposomes, including Doxil, can cause severe life-threatening hemodynamic changes in pigs. The reaction is due to complement activation, and it is characterized by massive pulmonary hypertension, systemic hypotension, and severe cardiac abnormalities including falling cardiac output, tachy-or bradycardia with arrhythmia. There were no data suggesting the involvement of cerebrovascular changes in this reaction: however, clinical observations allowed this hypothesis. Here we measured the accompanying changes during liposome infusion by monitoring pulsatile electrical impedance (rheoencephalogram- REG) on the skull (n = 24 pigs, 57 trials, 19 types of liposomes). A transient but significant decrease of REG pulse amplitudes followed the injection of liposomes (78.43% in the total sample, and 91.66% in the Doxil subgroup; P = 0.003, n = 12), indicating the involvement of cerebrovascular reaction during liposome infusion.

Original languageEnglish
Pages (from-to)3-14
Number of pages12
JournalJournal of Liposome Research
Volume15
Issue number1-2
DOIs
Publication statusPublished - júl. 25 2005

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Bodo, M., Szebeni, J., Baranyi, L., Savay, S., Pearce, F. J., Alving, C. R., & Bünger, R. (2005). Cerebrovascular involvement in liposome-induced cardiopulmonary distress in pigs. Journal of Liposome Research, 15(1-2), 3-14. https://doi.org/10.1081/LPR-64523