Cercopithecus aethiops monkey as a reliable model for in vitro study of T cell depletion of bone marrow with Campath-1 plus complement.

D. T. Phan, M. Benczur, J. Gidáli, I. Fehér, V. Harsányi, L. Nemes, G. Petrányi, S. R. Hollán

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Abstract

T-lymphocyte markers of peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of C. aethiops monkeys were studied by using anti-human monoclonal antibodies. The results show that C. aethiops T lymphocytes express surface markers which react specifically with anti-human MoAbs including CD3, CD4, CD8, CD2. However, very few CD3-positive cells were found, in contrast to the abundance in CD8+ cells. There is a high conservation of receptors forming E rosettes with AET-treated SRBCs, and antigens reacting with the anti-human T and B cell monoclonal antibody (Campath-1). The present findings indicate that C. aethiops can be used as a new experimental model for studies on T-cell depletion from bone marrow with Campath-1 MoAb + rabbit C.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalFolia haematologica (Leipzig, Germany : 1928)
Volume116
Issue number1
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Hematology

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