Abstract
The widely distributed neurotransmitter serotonin is unquestionably involved in many essential facets of human physiology and behaviour and continues to attract great scientific and public interest. Research related to serotonin became a success story of pharmacology, neurology and psychiatry and other biomedical fields. Several drugs that led to the revolution of the pharmacotherapy of depression, anxiety disorders, schizophrenia, migraine, irritable bowel disease or vomiting act on the serotonergic neurotransmission. The first part of this article gives a short summary of our current knowledge about serotonin, namely anatomy, receptors, functions and drugs used in therapy. In the second part the authors focussed on the results of the last ten year research in selected serotonin-related fields achieved by the Laboratory of Neurochemistry and Experimental Medicine of the previous National Institute of Psychiatry and Neurology and it's successor at Semmelweis University. These include preclinical and clinical works in the fields of neurosciences and pharmacology, namely migraine, epilepsy, anxiety, depression, sleep regulation and the morphological and functional effects of ecstasy (3,4- methylenedioxymethamphetamine, MDMA).
| Original language | Hungarian |
|---|---|
| Pages (from-to) | 73-92 |
| Number of pages | 20 |
| Journal | Orvoskepzes |
| Volume | 84 |
| Issue number | SUPPL. 2 |
| Publication status | Published - 2009 |
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Keywords
- 5-HT receptors
- Anxiety
- Cellular signals
- CGRP
- Depression
- Drug therapy
- Ecstasy
- Epilepsy
- Gene × environment interaction
- Genetic polymorphism
- MDMA
- Migraine
- Neuronal damage
- Serotonin (5-HT)
- Serotonintransporter
- Sleep
ASJC Scopus subject areas
- Medicine(all)
Cite this
A szerotonin a központi idegrendszerben : Kirándulás a neurobiológiától, genetikától a farmakológia, pszichiátria és neurológia felé. / Bagdy, G.; János, Filakovszky; Sándor, Kántor; Juhász, G.; Márton, Graf; Jakus, R.; Gonda, X.; Terézia, Zsombók; Ádori, C.; Brigitta, Balogh; Eszter, Kirilly; Dénes, Andó Rómeó; Lazáry, J.; Norbert, Gyöngyösi; Anita, Benko; Eszter, Molnár; Tamás, Kitka.
In: Orvoskepzes, Vol. 84, No. SUPPL. 2, 2009, p. 73-92.Research output: Article
}
TY - JOUR
T1 - A szerotonin a központi idegrendszerben
T2 - Kirándulás a neurobiológiától, genetikától a farmakológia, pszichiátria és neurológia felé
AU - Bagdy, G.
AU - János, Filakovszky
AU - Sándor, Kántor
AU - Juhász, G.
AU - Márton, Graf
AU - Jakus, R.
AU - Gonda, X.
AU - Terézia, Zsombók
AU - Ádori, C.
AU - Brigitta, Balogh
AU - Eszter, Kirilly
AU - Dénes, Andó Rómeó
AU - Lazáry, J.
AU - Norbert, Gyöngyösi
AU - Anita, Benko
AU - Eszter, Molnár
AU - Tamás, Kitka
PY - 2009
Y1 - 2009
N2 - The widely distributed neurotransmitter serotonin is unquestionably involved in many essential facets of human physiology and behaviour and continues to attract great scientific and public interest. Research related to serotonin became a success story of pharmacology, neurology and psychiatry and other biomedical fields. Several drugs that led to the revolution of the pharmacotherapy of depression, anxiety disorders, schizophrenia, migraine, irritable bowel disease or vomiting act on the serotonergic neurotransmission. The first part of this article gives a short summary of our current knowledge about serotonin, namely anatomy, receptors, functions and drugs used in therapy. In the second part the authors focussed on the results of the last ten year research in selected serotonin-related fields achieved by the Laboratory of Neurochemistry and Experimental Medicine of the previous National Institute of Psychiatry and Neurology and it's successor at Semmelweis University. These include preclinical and clinical works in the fields of neurosciences and pharmacology, namely migraine, epilepsy, anxiety, depression, sleep regulation and the morphological and functional effects of ecstasy (3,4- methylenedioxymethamphetamine, MDMA).
AB - The widely distributed neurotransmitter serotonin is unquestionably involved in many essential facets of human physiology and behaviour and continues to attract great scientific and public interest. Research related to serotonin became a success story of pharmacology, neurology and psychiatry and other biomedical fields. Several drugs that led to the revolution of the pharmacotherapy of depression, anxiety disorders, schizophrenia, migraine, irritable bowel disease or vomiting act on the serotonergic neurotransmission. The first part of this article gives a short summary of our current knowledge about serotonin, namely anatomy, receptors, functions and drugs used in therapy. In the second part the authors focussed on the results of the last ten year research in selected serotonin-related fields achieved by the Laboratory of Neurochemistry and Experimental Medicine of the previous National Institute of Psychiatry and Neurology and it's successor at Semmelweis University. These include preclinical and clinical works in the fields of neurosciences and pharmacology, namely migraine, epilepsy, anxiety, depression, sleep regulation and the morphological and functional effects of ecstasy (3,4- methylenedioxymethamphetamine, MDMA).
KW - 5-HT receptors
KW - Anxiety
KW - Cellular signals
KW - CGRP
KW - Depression
KW - Drug therapy
KW - Ecstasy
KW - Epilepsy
KW - Gene × environment interaction
KW - Genetic polymorphism
KW - MDMA
KW - Migraine
KW - Neuronal damage
KW - Serotonin (5-HT)
KW - Serotonintransporter
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=82955251658&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82955251658&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:82955251658
VL - 84
SP - 73
EP - 92
JO - Orvoskepzes
JF - Orvoskepzes
SN - 0030-6037
IS - SUPPL. 2
ER -