Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm

A report of two cases

Nóra Eros, Márta Marschalko, Katalin Balassa, Bernadett Hídvégi, József Szakonyi, Sándor Ilniczky, Katalin Borka, Attila Kovács, Gyula Bottlik, Judit Hársing, Judit Csomor, Ágota Szepesi, A. Matolcsy, S. Kárpáti, J. Demeter

Research output: Article

3 Citations (Scopus)

Abstract

CD4+/CD56+hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.

Original languageEnglish
Pages (from-to)301-304
Number of pages4
JournalJournal of Neuro-Oncology
Volume97
Issue number2
DOIs
Publication statusPublished - ápr. 2010

Fingerprint

Cerebrospinal Fluid
Meningeal Neoplasms
Central Nervous System
Natural Killer Cells
Non-Hodgkin's Lymphoma
Lymphoma
Neoplasms
Flow Cytometry
Lymph Nodes
Bone Marrow
Drug Therapy
Skin

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

Cite this

Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm : A report of two cases. / Eros, Nóra; Marschalko, Márta; Balassa, Katalin; Hídvégi, Bernadett; Szakonyi, József; Ilniczky, Sándor; Borka, Katalin; Kovács, Attila; Bottlik, Gyula; Hársing, Judit; Csomor, Judit; Szepesi, Ágota; Matolcsy, A.; Kárpáti, S.; Demeter, J.

In: Journal of Neuro-Oncology, Vol. 97, No. 2, 04.2010, p. 301-304.

Research output: Article

Eros, N, Marschalko, M, Balassa, K, Hídvégi, B, Szakonyi, J, Ilniczky, S, Borka, K, Kovács, A, Bottlik, G, Hársing, J, Csomor, J, Szepesi, Á, Matolcsy, A, Kárpáti, S & Demeter, J 2010, 'Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: A report of two cases', Journal of Neuro-Oncology, vol. 97, no. 2, pp. 301-304. https://doi.org/10.1007/s11060-009-0026-y
Eros N, Marschalko M, Balassa K, Hídvégi B, Szakonyi J, Ilniczky S et al. Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: A report of two cases. Journal of Neuro-Oncology. 2010 ápr.;97(2):301-304. https://doi.org/10.1007/s11060-009-0026-y
Eros, Nóra ; Marschalko, Márta ; Balassa, Katalin ; Hídvégi, Bernadett ; Szakonyi, József ; Ilniczky, Sándor ; Borka, Katalin ; Kovács, Attila ; Bottlik, Gyula ; Hársing, Judit ; Csomor, Judit ; Szepesi, Ágota ; Matolcsy, A. ; Kárpáti, S. ; Demeter, J. / Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm : A report of two cases. In: Journal of Neuro-Oncology. 2010 ; Vol. 97, No. 2. pp. 301-304.
@article{c200a6bc362b4587b564fadfc884b7d4,
title = "Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm: A report of two cases",
abstract = "CD4+/CD56+hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.",
keywords = "Blastic NK-cell lymphoma, CD4+/CD56+ hematodermic neoplasm, Central nervous system involvement, Cerebrospinal fluid analysis, Prophylactic intrathecal chemotherapy",
author = "N{\'o}ra Eros and M{\'a}rta Marschalko and Katalin Balassa and Bernadett H{\'i}dv{\'e}gi and J{\'o}zsef Szakonyi and S{\'a}ndor Ilniczky and Katalin Borka and Attila Kov{\'a}cs and Gyula Bottlik and Judit H{\'a}rsing and Judit Csomor and {\'A}gota Szepesi and A. Matolcsy and S. K{\'a}rp{\'a}ti and J. Demeter",
year = "2010",
month = "4",
doi = "10.1007/s11060-009-0026-y",
language = "English",
volume = "97",
pages = "301--304",
journal = "Journal of Neuro-Oncology",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "2",

}

TY - JOUR

T1 - Central nervous system involvement in CD4+/CD56+ hematodermic neoplasm

T2 - A report of two cases

AU - Eros, Nóra

AU - Marschalko, Márta

AU - Balassa, Katalin

AU - Hídvégi, Bernadett

AU - Szakonyi, József

AU - Ilniczky, Sándor

AU - Borka, Katalin

AU - Kovács, Attila

AU - Bottlik, Gyula

AU - Hársing, Judit

AU - Csomor, Judit

AU - Szepesi, Ágota

AU - Matolcsy, A.

AU - Kárpáti, S.

AU - Demeter, J.

PY - 2010/4

Y1 - 2010/4

N2 - CD4+/CD56+hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.

AB - CD4+/CD56+hematodermic neoplasm, formerly known as blastic NK-cell lymphoma, is an uncommon, aggressive non-Hodgkin's lymphoma with cutaneous, lymph node, and bone marrow involvement at presentation. The disease is characterized by early leukemic phase; however, central nervous system involvement is rarely reported. Herein we describe two cases of CD4+/CD56+ hematodermic neoplasm with meningeal manifestation. Microscopic analysis and flow cytometry of cerebrospinal fluid proved to be diagnostic; however, imaging studies were not informative. These observations call attention to the possibility of central nervous system involvement, which could be more common than expected previously. Authors recommend routine cerebrospinal fluid analysis and prophylactic intrathecal chemotherapy in patients with this highly aggressive disease.

KW - Blastic NK-cell lymphoma

KW - CD4+/CD56+ hematodermic neoplasm

KW - Central nervous system involvement

KW - Cerebrospinal fluid analysis

KW - Prophylactic intrathecal chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=77950459878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950459878&partnerID=8YFLogxK

U2 - 10.1007/s11060-009-0026-y

DO - 10.1007/s11060-009-0026-y

M3 - Article

VL - 97

SP - 301

EP - 304

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

SN - 0167-594X

IS - 2

ER -