The anti-complement immunofluorescence method was used to demonstrate EBNA in B lymphocytes separated from the peripheral blood of patients with infectious mononucleosis (IM) or other diseases. In the acute phase of IM of Epstein-Barr virus (EBV) origin, 0.5-1% of the B lymphocytes proved to be positive in 6 of the 8 patients tested. In 2 of the positive cases the test was repeated 20 and 26 days, respectively, after clinical symptoms had appeared; the result was negative in both cases. No EBNA-positive cells were found in the peripheral blood of 17 patients with Hodgkin's disease, 3 with systemic lupus erythematosus and 2 with lymphosarcoma. It is supposed that EBNA-positive cells appear in detectable amounts exclusively in the acute phase of EBV infection.
|Number of pages||5|
|Journal||Acta microbiologica Academiae Scientiarum Hungaricae|
|Publication status||Published - nov. 2 1979|
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