CD45 (PTPRC) as a candidate gene in multiple sclerosis

Tamara Vyshkina, Thomas P. Leist, Yin Yao Shugart, B. Kálmán

Research output: Article

16 Citations (Scopus)

Abstract

The 77C →G polymorphism in exon 4 of CD45 or protein tyrosine phosphatase receptor-type C (PTPRC) has been investigated in families with multiple sclerosis (MS) and in several cohorts of sporadic patients and controls, however with conflicting results. To better understand the role of this functionally important polymorphism in MS, we investigated the transmission of the 'G' allele from unaffected parents to their affected children in 176 families by using linkage and association statistics. The 'G' allele was transmitted to the affected offspring in five of the seven pedigrees carrying this allele and the TRANSMIT program detected association with a P = 0.0342. We conclude that the 77C →G PTPRC polymorphism is present and preferentially transmitted in a small subgroup (

Original languageEnglish
Pages (from-to)614-617
Number of pages4
JournalMultiple Sclerosis
Volume10
Issue number6
DOIs
Publication statusPublished - dec. 2004

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CD45 Antigens
Multiple Sclerosis
Alleles
Genes
Pedigree
GTP-Binding Proteins
Exons
Parents

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

CD45 (PTPRC) as a candidate gene in multiple sclerosis. / Vyshkina, Tamara; Leist, Thomas P.; Shugart, Yin Yao; Kálmán, B.

In: Multiple Sclerosis, Vol. 10, No. 6, 12.2004, p. 614-617.

Research output: Article

Vyshkina, Tamara ; Leist, Thomas P. ; Shugart, Yin Yao ; Kálmán, B. / CD45 (PTPRC) as a candidate gene in multiple sclerosis. In: Multiple Sclerosis. 2004 ; Vol. 10, No. 6. pp. 614-617.
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