CD-15 antigen detected by the VIM-D5 monoclonal antibody for prediction of ability to achieve complete remission in acute nonlymphocytic leukemia1

J. Hołowiecki, D. Lutz, S. Krzemień, B. Stella-Hołowiecka, F. Graf, G. Kelenyi, V. Schranz, V. Callea, M. Brugiatelli, A. Neri, T. Magyarlaki, R. Ihle, K. Jagoda, E. Rudzka

Research output: Article

12 Citations (Scopus)

Abstract

The prognostic value of cell differentiation antigens detected with the monoclonal antibodies of VI series was studied in 242 cases of acute nonlymphoblastic leukemia (ANLL) treated in 7 cooperating centers. A significantly higher complete remission rate was observed in patients with a higher expression of CD-15 antigen detected by VIM-D5 antibody than in those with lower values. These significant differences were proved when comparing subgroups with VIM-D5 positivity of blastic cells < 15 and > 15% (p < 0.01) as well as in the subgroups with values < 50% (median value) and ≥ 50% (p < 0.02). Our studies suggest the VIM-D5 positivity of ANLL cells to be favourable prognostic factor predicting the ability to achieve complete remission. Further studies are needed to establish whether the expression of the VIM-D5-defined antigen may serve as a prognostic factor related to survival.

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalActa Haematologica
Volume76
Issue number1
DOIs
Publication statusPublished - jan. 1 1986

ASJC Scopus subject areas

  • Hematology

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    Hołowiecki, J., Lutz, D., Krzemień, S., Stella-Hołowiecka, B., Graf, F., Kelenyi, G., Schranz, V., Callea, V., Brugiatelli, M., Neri, A., Magyarlaki, T., Ihle, R., Jagoda, K., & Rudzka, E. (1986). CD-15 antigen detected by the VIM-D5 monoclonal antibody for prediction of ability to achieve complete remission in acute nonlymphocytic leukemia1. Acta Haematologica, 76(1), 16-19. https://doi.org/10.1159/000206011